Maternal Serum Placental Leucine Aminopeptidase as a Predictor of Pregnancy Outcomes

	Maternal Serum Placental Leucine Aminopeptidase as a Predictor of Pregnancy Outcomes
Iraqi Postgraduate Medical Journal
Article 5, Volume 19, Issue 3, 2020, Pages 205-212 PDF (0 K)
Abstract
BACKGROUND: Placental leucine aminopeptidase is a glycoprotein, known as oxytocinase. It helps to maintain normal pregnancy to term, also it is involved in fetal development, maintenance of homeostasis during pregnancy, blood pressure regulation, memory retention, antigen presentation, and cancer development. OBJECTIVE: To evaluate the value of maternal serum placental leucine aminopeptidase levels as a predictor of pregnancy outcomes. PATIENTS AND METHODS: Hundred pregnant women were included in the study, they were divided into four groups, 25 pregnant women with hypertensive disorder of pregnancy, 25 pregnant women with gestational diabetes and 25 pregnant women with intrauterine fetal death at a gestational age between 28 - 41 weeks, another 25 healthy pregnant women as a control group with gestational age range 37 - 40 weeks. Serum levels of placental leucine aminopeptidase were measured using Enzyme-linked immunosorbent assay (ELISA) method for all study groups at the time of presentation. It is a case - control study that was conducted at AL-Yarmook Teaching Hospital, department of obstetrics and gynecology. RESULTS: Serum placental leucine aminopeptidase concentration significantly lower in pregnant women presented with fetal death group was(mean ± SD)61.6 ± 15.8IU/ml compared to pregnant women with hypertensive disorders in pregnancy, gestational diabetes mellitus and healthy pregnant women were (83.2 ± 12.51IU/mL, 85.0 ± 13.11IU/mL and 108.9 ± 19.1IU/mL), respectively. Receiver operating characteristic( ROC) curve analysis showed that the result of serum placental leucine aminopeptidase level for predicting perinatal mortality among pregnant women was (optimal cut point ≤78.98, sensitivity100%, specificity 73.3and accuracy 80.0%). CONCLUSION: Maternal serum placental leucine aminopeptidase was low among patients with hypertensive disorders in pregnancy, gestational diabetes mellitus and much lower among patients presented with fetal death compared to healthy pregnant women. Low serum placental leucine aminopeptidase level had high sensitivity and specificity for predicting perinatal mortality.
Keywords
placental leucine aminopeptidase; hypertensive disorders of pregnancy; gestational diabetes mellitus and fetal death

Statistics Article View: 329 PDF Download: 152