Oral manifestations, microbial study and enzyme analysis in patients with peptic ulcer

D. Abdul-Razaq, Fawaz; M. Idan, Hayder

	Oral manifestations, microbial study and enzyme analysis in patients with peptic ulcer
Journal of baghdad college of dentistry
Article 1, Volume 23, Issue 2, 2011, Pages 56-60
Authors
Fawaz D. Abdul-Razaq; Hayder M. Idan
Abstract
ABSTRACTBackground: Peptic ulcer disease is one of the most common diseases affecting the gastrointestinal tract. It causesinflammatory injuries in the gastric or duodenal mucosa, with extension beyond the submucosa into the muscularismucosa (1).The aims of this study was to determine the prevalence of oral manifestations in the peptic ulcer patients,isolate and identify different microorganism (aerobic, anaerobic and fungi), from oral micro flora from patients withpeptic ulcer and detect the enzymes level in saliva including alkaline phosphatase (ALP), total salivary protein (TSP)and lactate dehydrogenase (LDH) in relation to peptic ulcer and comparison with healthy control.Subjects, materials and method: The study included 35 patients with peptic ulcer (21male and 14 female) and groupof 20 healthy control (7 male and 13 female).Results: The most frequent oral manifestations in the patients with peptic ulcer, in our study was burning mouthsyndrome, tooth erosion and aphthous ulcer, while angular chelitis, bad odor and white coated tongue, were fairlyfrequent. The most frequent microorganisms in the patients with peptic ulcer, in our study was Staphylococcus aureusand Candida albicans. A significant relationship of TSP and LDH enzymes in patients with peptic ulcer as comparedto healthy control. However, slightly increased levels of ALP in peptic ulcer patients as compared to healthy control,but no statistically relationship were established.Conclusions: The most frequent oral manifestations in peptic ulcer patients were burning mouth syndrome, thentooth erosion and aphthous ulcer. The prevalence of the oral manifestation in peptic ulcer patients increased withinage. High levels of total salivary protein and alkaline phosphatase enzymes in patients with peptic ulcer than healthycontrol. Low level of saliva LDH enzyme in patients with peptic ulcer than healthy control.The frequent study showeda difference in oral microbial isolation between patients with peptic ulcer and healthy control; therefore, frequentoral examination of patients with peptic ulcer is mandatory.Key words: oral manifestations, microbial study, enzyme analysis, peptic ulcer. (J Bagh Coll Dentistry 2011;23(56-60).

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