Preparation, Characterization and Evaluation Biological Activity of Cobalt (II) with Mixed Ligands complexes

Al-Bayati, Ahlam Mohammed Yaseen; Dawood, Zuhoor Fathi

doi:10.33899/edusj.2020.128321.1110

	Preparation, Characterization and Evaluation Biological Activity of Cobalt (II) with Mixed Ligands complexes
Journal of Education and Science
Article 29, Volume 30, Issue 2, 2021, Pages 1-18 PDF (1.22 M)
Document Type: Research Paper
DOI: 10.33899/edusj.2020.128321.1110
Authors
Ahlam Mohammed Yaseen Al-Bayati^* ¹; Zuhoor Fathi Dawood²
¹Department of Chemistry / College of Science / University of Mosul
²Department of Chemistry / College of Education for Pure Sciences / University of Mosul
Abstract
New cobalt (II) complexes with mixed ligands including [(2- oxime-4-hydrazone) pentane (L₁H) and 2-chlorobenzaldehyde thiosemicarbazone(T₁H) ,or 3,4-dimethoxy acetophenone thiosemicarbazone (T₂H); glycine (GH) or metformin (mf)] have been prepared in both pH (6.5-7) and (9.5-10) using classical and microwave techniques. The resulting complexes have been characterized using physio- chemical and spectral techniques. The study suggested that the complexes have the generalformulate [Co(L₁H)(TH)(BH)](CH₃COO)₂and[Co(L₁)(TH)(G)]or[Co(L₁)(T)(mf)] at pH (6.5-7) and (9.5- 10), respectively {where TH= T₁H or T₂H; T= deprotonated T₁H or T₂H; L₁H=L₁=deprotenated; BH= GH or mf; G= deprotonated GH]. Hexacoordinated mononuclear complexes having distorted octahedral geometries have been investigated. The biologicall activity of the ligands and complexes have been evaluated by agar plate diffusion technique against Echerichia coli, Klipsila pnnemoia, Staphylococcus aureus and Pseudomonas aeruginosa. Some compounds have been found to have antibacterial activity.
Keywords
Mixed ligands; Cobalt (II) complexes; thiosemicarbazone; metformin glycine

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