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Study of Interleukin 6 as marker of inflammation and a predictor of in-hospital complications in patients with acute coronary syndrome | ||
| The Medical Journal of Basrah University | ||
| Article 14, Volume 38, Issue 2, 2020, Pages 115-119 PDF (428.78 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2020.128197.1032 | ||
| Authors | ||
| Sally Abdul-Raheem Alhumrani1; Nidham Mohammed Jamalludeen* 2; Abdulameer Abdulbari Abdulhameed3 | ||
| 1Dept. of Microbiology College of Medicine University of Basrah | ||
| 2Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq | ||
| 3Department of Medicine College of Medicine University of Basrah Basrah, Iraq | ||
| Abstract | ||
| Abstract: Background Although abnormal fatty deposits of infected arterial plaque play a major role in the formation of atherosclerotic plaque, activation of inflammatory cells plays a major role in the instability of the plaque and the cause of acute coronary syndrome. The aim of this study was to measure the level of interleukin-6 and to study its association with complications that occur in hospital in patients with acute coronary syndrome. Method: One hundred and twenty-five patients with acute coronary syndrome and 120 healthy individuals as a control group were included in this study. According to ECG and serum troponin changes, the patient group was classified into three ST-elevated myocardial infarction, ST non-elevated myocardial infarction and unstable angina. Sandwich ELISA was used by commercial groups (LEGAND MAX TM) for the IL-6 assay. Result: This study shows significantly significant differences in the level of IL-6 in patients with acute coronary syndrome (73.37 pg / dL) compared to the control group (9.47 pg / dL) (P value 0.001) There were no significant differences at the level of IL-6 in patients with acute coronary syndrome and conventional risk factors (P. value <0.05). There were significant differences in the level of IL-6 in all forms of ACS. (P. value 0.001). And those patients who had complications in hospital had a higher IL-6 level (92.89 Pg / dl) than those without complications (68.83 Pg / dl) P. value (0.012). Conclusion: This study indicated that IL-6 was significantly elevated in ACS patients | ||
| Keywords | ||
| ACS,,; ,،,؛interleukin-6,,; ,،,؛STEMI,,; ,،,؛NSTEMI,,; ,،,؛unstable angina | ||
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