Hussein, H., Lazim, H., Muhsen, A. (2020). Association of Carotid Intima Media Thickness with the Severity of Coronary Artery Disease. , 20(2), 172-177. doi: 10.52573/ipmj.2020.168626
Hafidh Jaleel Hussein; Hussein Jubair Lazim; Ameer Adnan Muhsen. "Association of Carotid Intima Media Thickness with the Severity of Coronary Artery Disease". , 20, 2, 2020, 172-177. doi: 10.52573/ipmj.2020.168626
Hussein, H., Lazim, H., Muhsen, A. (2020). 'Association of Carotid Intima Media Thickness with the Severity of Coronary Artery Disease', , 20(2), pp. 172-177. doi: 10.52573/ipmj.2020.168626
Hussein, H., Lazim, H., Muhsen, A. Association of Carotid Intima Media Thickness with the Severity of Coronary Artery Disease. , 2020; 20(2): 172-177. doi: 10.52573/ipmj.2020.168626

Association of Carotid Intima Media Thickness with the Severity of Coronary Artery Disease

Iraqi Postgraduate Medical Journal
Article 11, Volume 20, Issue 2, 2021, Pages 172-177    PDF (247.54 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2020.168626
Authors
Hafidh Jaleel Hussein1; Hussein Jubair Lazim2; Ameer Adnan Muhsen2
1Ibn Al Baladi Pediatrics and Obstetrics Hospital, Baghdad, Iraq
2Ibn Al- Nafis Cardiovascular Hospital- Baghdad, Iraq
Abstract
BACKGROUND: 
Nevertheless, of a number of prevention schemes, coronary artery illness continues to exist as                    the leading cause of death worldwide disease. Within this context, Intima media thickness is believed to have a key role in the atherosclerosis initiation. The development of ultrasound machines, advances in echocardiographic devices with great determination transducers facilitate total study of carotid –intima media thickness (C-IMT).                                            
OBJECTIVE:
To investigate the relationship of Carotid Intima Media Thickness with the severity of coronary vessels illness.                                                                                                             
PATIENTS AND METHODS:
Through the sections of a cross sectional multicenter diagnostic accuracy survey assessing C-IMT in a total of one hundred thirty two  patients preselected to undergo coronary angiography. For this purpose, patients' demographic data and the disease- associated risk factors were evaluated. Two dimensional transthoracic echocardiographic measurements were done. Furthermore, C-IMT measurements were obtained as it specified by the American society of echocardiography (ASE). Consequences of the study sample as all were revised according to angiographic findings.
RESULTS:
 In the present study, a total of 132 patients, of them 72 patients were included in the CAD group while 60 patients with no CAD served as control. The most important risk factors for CAD are modifiable, while family history of CAD ( a non- modifiable risk factor) was not significant                         (P value=0.348). There was direct and significant correlation between C-IMT and severity of CAD. ROC analysis for validity of C-IMT to discriminate between multiple vessels disease and no vessel involvement is excellent (AUC= 0.961, cut point > 1.04mm, sensitivity=92.9%. specificity=86.7%). C-IMT is fair to discriminate between single vessel disease and no vessel involvement (AUC=0.738, cut point ˃ 0.84mm, sensitivity 100%), so if correlated with age, C-IMT above 0.84 is utilized as  can  be used as a detached theme to guessing of CAD.                                  
CONCLUSION:
C-IMT is simple, inexpensive and reproducible parameter that is utilized to be showing aid to the presence and severity of CAD particularly earlier indications showing in great danger for sick people.                                                                 
 
 
Keywords
Carotid Intima- Media Thickness; coronary artery disease; Echocardiography
References
  1. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation. 1986; 74:1399–6.
  2. Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb. 1991; 11:1245–9.
  3. Belington RP, Miller ME, Herrington D, et al. Rationale, design, and baseline characteristics of the prospective randomised evaluation of the vascular effects of norvasc trial (PREVENT). Am J Cardiol 1997; 80:1087–90.
  4. Crouse JR III, Byington RP, Bond MG, et al. Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC II). Am J Cardiol 1995; 75:455–9.
  5. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340:14-22.
  6. Roman MJ, Naqvi TZ, Gardin JM, Gerhard-Herman M, Jaff M, Mohler E. Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology. J Am Soc Echocardiogr. 2006; 19:943-954.
  7. McMahan C, Gidding S, Viikari J, et al. Association of pathobiologic determinants of atherosclerosis in youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from the Cardiovascular Risk in Young Finns Study). J Am Coll Cardiol. 2007; 100:1124–9.
  8. Lloyd-Jones D, Adams R, Carnethon M, et al.  Heart disease and stroke statistics update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009; 119: 21–181.                                                                            
  9. Deelstra, M.H. & Jacobson, C. Cardiac catheterization. In: S.L. Woods, E.S.S. Froelicher, S.U. Motzer & E.J. Bridges (eds), Cardiac Nursing, 5th edn. Lippincott Williams and Wilkins, Philadelphia, 2005; 20: 459–77.
  10.  Olade, R. & Safi, A. (2006). Cardiac catheterization (left heart). eMedicine. Retrieved online on 30th August 2006 from http://www.emedicine.com/MED/topic2958.htm.
  11.  Peter Libby. Atherosclerosis. Mark A. Creager, MD, Joshua A. Beckman, MD, MS, Joseph Loscalzo, MD, PhD. Vascular Medicine, A Companion to Braunwald's Heart Disease. Second edition, Saunders, an imprint of Elsevier Inc, 2013; 8: 120.
  12. D.E. Newby,N.R. Grubb, A. Bradbury. Cardiovascular disease.  Walker BR, Colledge NR. Davidson's principles and practice of medicine.22nd edition, Elsevier Health Sciences, 2014; 18: 580.
  13.  Jaggi H, Kearns EH. Risk Factors in Coronary Artery Disease. Missouri: University of Missouri-Columbia School of Health Proffesions, 2012 Available at: http://shp.missouri. edu/vhct/ case2000/conclusion. htm.
  14.  Annet Kirabo and David G. Harrison. Hypertension as a risk factor for Atherosclerosis. Hong Wang and Cam Patterson. Atherosclerosis Risks, Mechanisms and Therapies. First Edition, John Wiley and Sons, 2015; 6: 63.
  15.  Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444: 875–80.
  16.  National Lung Heart and Blood Institute. Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J Am Med Assoc 2001; 285: 2486–97.
  17. Flegal KM, Graubard BI, Williamson DF, et al. Excess deaths associated with underweight, overweight, and obesity. J Am Med Assoc 2005; 193: 1861–7.
  18.  Fontaine KR, Redden DT, Wang C, et al. Years of life lost due to obesity. J Am Med Assoc 2003; 198: 187–93.
  19.  Martin O,Flaherty, Susanna Sans-Menendez, Simon Capewell and TorbanJorgensen. Atherosclerotic Cardiovascular Disease: Scope of the problem and its determinents. Stephen Gielen, Guy de Backer, Massmo F. Piepoli and David Wood. The ESC Textbook of Preventive Cardiology. First Edition, Oxford University press, 2015; 1: 8-9.
  20.  William F Armstrong and Thomas Ryan, Echocardiography and Coronary Artery Disease, William F. Armstrong and Thomas Ryan.  Feigenbaum’s Echocardiography, 7th edn, Lippincott Williams & Wilkins. 2010; 16: 435.
Statistics
Article View: 265
PDF Download: 154


Journal Management System. Powered by iJournalPro.com