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Synthesis of new 1,2 dithiol 3-thione fluoroquinolone esters possessing anticancer activity in-vitro | ||
| Iraqi Journal of Veterinary Sciences | ||
| Article 1, Volume 26, Suppl. IV - Serial Number 5, 2012, Pages 115-121 PDF (321.06 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/ijvs.2012.168748 | ||
| Authors | ||
| B.B. Saeed1; M.A. Al-Iraqi1; F.T. Abachi2 | ||
| 1Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq | ||
| 2Department of Pharmaceutical Science, College of Pharmacy, University of Mosul, Mosul, Iraq, | ||
| Abstract | ||
| Three 1,2 dithiole 3-thion fluoroquinolone esters (2-4) were prepared via condensation of (p-hydroxyl phenyl) -1,2dithiole- 3-thione with fluoroquinolones (Ciprofloxacin, Gatefloxacin and Moxifloxacin). The biological activity of these compounds was assayed against 60 types of cancer cells in vitro. The compound 2 (NSC=760553) showed anticancer activity against renal cell, while the comound 4 (NSC=760555) show activity against three types of cancer cell. The expected mechanism of their activity is that 1,2dithiole 3-thione derivatives may give H2S as new gas transmitter which play an important role in the biological systems. | ||
| Keywords | ||
| Fluoroquinolone; Anticancer; Ciprofloxacin; Gatefloxacin; Moxifloxacin | ||
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