The role of tumor suppressor protein Tp63 in oral squamous cell carcinoma

Pannone, Giusseppe; A.H. Hindy, Suha

	The role of tumor suppressor protein Tp63 in oral squamous cell carcinoma
Journal of baghdad college of dentistry
Article 1, Volume 21, Issue 2, 2009, Pages 78-81
Authors
Giusseppe Pannone; Suha A.H. Hindy
Abstract
ABSTRACTBackground: The present study was conducted on oral squamous cell carcinoma (OSCC) which is the most commonoral malignancies with main objective of showing the expression of p63 in OSCC.Materials and methods: This study comprised a total of (93) patients diagnosed as OSCC.,(62)males and (31) females.The cases include: well differentiated SCC.(32)cases, moderately differentiated SCC.(40) and poorly differentiatedSCC.(21)cases. The expression of p63 gene was carried out on 4μm tumor sections using Immuno histochemicalstaining of p63 antibody. The data demonstrated the mean percentage expression of p63 in well, moderately andpoorly differentiated SCC.Results: Results showed that p63 expression was observed as positive diffuse reactivity in(38) cases (40.86%), positivebasal Para basal reactivity in (19)cases (20.34%), positive basal reactivity in (34) cases (36.56%) and negativereactivity in( 2) cases (2.15%). Results also showed p63 expression was increased in high grade tumors of size >1.5cmand metastatic dissemination of lymph nodes with diffuse and basal Para basal pattern of distribution.Scoring analysis showed more than 50% of cases present with score 26-50% of expression.Conclusion: These data found that the P63 nuclear positivity was extended from the basal- Para basal layers to thewhole epithelial layers in both moderately and poorly differentiated tumors, and P63 staining was more uniform andhomogenous for the well- differentiated tumor areas.Key words: HNSCC= Head and Neck squamous cell carcinoma; OSCC= oral squamous cell carcinoma. J Bagh CollDentistry 2009; 21(2):78-81)

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