- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Toxic Effect of Inhalation Polyurethane in Lungs, Liver, and Kidneys Fume in White Male Mice | ||
| Engineering and Technology Journal | ||
| Article 2, Volume 37, 11A, 2019, Pages 460-463 PDF (616.44 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.30684/etj.37.11A.2 | ||
| Authors | ||
| Sura M. Ahmed; Amel A. Hussain | ||
| Biotechnology, Applied Science Department, University of Technology - Iraq | ||
| Abstract | ||
| In this study, the toxic effect of exposure to inhalation of polyurethane resin fumes by White Male Mice was evaluated over 36 days. The study included the use of the inhalation method in an exposition room filled with the fume chemical to a period of 10, 20 and 40 minutes per day, and were then transferred to the fumigant section of the animal house. The organs of the mice was dissected, and the change of the weight determined. The lungs, liver, kidneys tissues of the exposed mice showed typical structural structures when compared with the control group. The liver cells of the mice group exposed to polyurethane were revealed to expose to some hydrolysis and led to an increase in their size. In terms of lung, tissue was characterized by the presence of interstitial infiltration and bloody congestion. It was observed that water degeneration of the lining cells of the parts of the urinary tracts of the kidney with the infiltration of inflammatory cells in the interstitial tissue. These results suggest that exposure of white mice to polyurethane coating fumes may cause observed harmful effects and cause serious health problems to their liver and lung. | ||
| Keywords | ||
| Volatile organic compounds; Histological study; Body weight; paint thinner | ||
| References | ||
|
[1] K.V. Akpan, T.O. Sogbanmu and A.A. Otitoloju, “Effects of Volatile Organic Solvents Inhalation on Hematological and Histological Indices of Mus Musculus,” Curr Advanc Environ Sci, Vol. 2, No. 2, pp. 46-51, 2014. [2] K.C. Patrick-Iwuanyanwu, E.A. Okon, N.W. Areh, and M.O. Wegwu, “Toxicological Effect of Inhalation Exposure to Nitrocellulose Paint Thinner Fumes in Wistar Albino Rats,” Archives of Applied Science Research Vol. 5, No. 1, pp. 264-269, 2013. [3] F.U. Igwe, H.W. Wosu, and C.U. Ogunka-Nnoka, “Hepatic Effects of the Dermal Absorption of Emulsion Paint Solution by Albino Rats,” International Journal of Scientific and Engineering Research, Vol. 8, No. 2, pp. 425, 2017. [4] H.M. Aslam, S. Saleem, S. German, and W.A. Qureshi, “Harmful Effects of Shisha: Literature Review,” International Archives of Medicine, Vol. 7, No. 1, pp. 16, 2014. [5] J.D. Bancroft and M. Gamble, “Theory and practice in histological techniques,” ChurchillLivingstone, 6th ed, Edinburgh, 2008. [6] A.R. Dahl, I.M. Grossi, D.P. Houchens, L.J. Scovell, M.E. Placke, A.R. Imondi, G.D. Stoner, L.M. De Luca, D. Wang, and J.L. Mulshine, “Inhaled Isotretinoin (13-Cis Retinoic Acid) is an Effective Lung Cancer Chemopreventive Agent in A/J Mice at Low Doses, A pilot study,” Clinical Cancer Research, Vol. 6, No. 8, pp. 3015-3024, 2000. [7] F.E. Uboh and S. Ufot, “Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats,” J. Clin. Toxicol, Vol. 3, No. 5, pp.2-6, 2013. [8] I. Lacroix, M. Lapeyre‐Mestre, H. Bagheri, A. Pathak, J.L. Montastruc, and Club de Reflexion des cabinets de Groupe de Gastro‐Enterologie (CREGG) and General Practitioner Networks, “Nonsteroidal Anti‐inflammatory Drug‐induced Liver Injury: A Case–control Study in Primary Care,” Fundamental & Clinical Pharmacology, Vol. 18, No. 2, pp. 201-206. 2004. [9] B. Young, W. Stewart, D. Odowd and P. R. Wheater, “Wheater's Basic Pathology a Text, Atlas and Review of Histopathology,” Churchill Livingstone/Elsevier 5th ed., Edinburgh, 2011. [10] A.H. Silva, C. Locatelli, F.B. Filippin-Monteiro, P. Martin, N.J. Liptrott, B.G. Zanetti-Ramos, and A. Owen, “Toxicity and Inflammatory Response in Swiss Albino Mice after Intraperitoneal and Oral Administration of Polyurethane Nanoparticles,” Toxicology letters, Vol. 246, pp. 17-27, 2016. [11] L.M. Majeed and A.K. Abass, “Biological Effects of Different Doses of Piroxicam in Albino Males Rats,” Iraqi Journal of Science; Vol. 58, No.2C, pp.1009-1019, 2017. | ||
|
Statistics Article View: 624 PDF Download: 470 |
||