AL- Bassam, A., Kareem, H., Shaker, S. (2020). Association of Insulin Resistance with Overactive Bladder Syndrome in Female Patients. , 20(3), 221-226. doi: 10.52573/ipmj.2020.169710
Anwar Noori AL- Bassam; Hadeel Kadham Kareem; Saba Reyadh Shaker. "Association of Insulin Resistance with Overactive Bladder Syndrome in Female Patients". , 20, 3, 2020, 221-226. doi: 10.52573/ipmj.2020.169710
AL- Bassam, A., Kareem, H., Shaker, S. (2020). 'Association of Insulin Resistance with Overactive Bladder Syndrome in Female Patients', , 20(3), pp. 221-226. doi: 10.52573/ipmj.2020.169710
AL- Bassam, A., Kareem, H., Shaker, S. Association of Insulin Resistance with Overactive Bladder Syndrome in Female Patients. , 2020; 20(3): 221-226. doi: 10.52573/ipmj.2020.169710

Association of Insulin Resistance with Overactive Bladder Syndrome in Female Patients

Iraqi Postgraduate Medical Journal
Article 3, Volume 20, Issue 3, 2021, Pages 221-226    PDF (523 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2020.169710
Authors
Anwar Noori AL- Bassam; Hadeel Kadham Kareem; Saba Reyadh Shaker
Baghdad Teaching Hospital, Baghdad, Iraq
Abstract
BACKGROUND:
Overactive bladder Syndrome refers to a group of lower urinary tract symptoms related to the storage of urine in the bladder. Normally the bladder fills and stores urine without discomfort or leakage. The sensation of bladder fullness gradually increases until the need to void comes to conscious awareness. In those who have overactive bladder, however, the sensation to void is altered (and generally delayed) to the extent that involuntary urination may occur. current evidence suggests that it may be associated with insulin resistance  .
AIM OF STUDY:
We aimed to investigate the association of insulin resistance with overactive bladder in female patients.
PATIENT AND METHODS :
We prospectively conducted the study in our urogynecological department. Female patients aged between 30 and 76 years with or without overactive bladder syndrome  OABS symptoms were enrolled.  Fifty patients with OABS and  fifty age-matched controls without OABS were included in the study. Fasting serum insulin and fasting blood sugar  were measured. Insulin resistance value was obtained via the homeostasis model assessment of insulin resistance (HOMA-IR) calculator.
RESULTS:
There was no significant difference in the age, and mode of delivery ‎between ‎women with or ‎without overactive bladder (OAB), while BMI and parity ‎number ‎were significantly higher in OABS ‎women‎. FBS, fasting insulin (‎11.2‎‏ ‏vs‎. ‎7.9 𝛍U/ml‎‏)‏ ‎, HOMA-IR value (‎2.62‎‏ vs‎. ‎1.77) and insulin ‎resistance (IR) was ‎significantly higher in OABS women‎, in which 50% had IR while ‎‎12% had IR in ‎women with or without OABS.‎ In multivariate analysis insulin resistance (IR≥2.5) , age, increased BMI, higher parity, and CS ‎history were independent predictors of overactive bladder‎.
CONCLUSION:
-    insulin resistance is associated with overactive bladder syndrome, and about half of the women with overactive bladder presented with insulin resistance
-   Hyperinsulinemia is strongly associated with overactive bladder
-   Obesity is an independent predictor of overactive bladder
-   HOMA-IR equation can be used as diagnostic methods that assist in confirmation of overactive bladder diagnosis by 20 – 25% additional increase in the index of suspicion.
 
 
Keywords
insulin resistance; overactive bladder; Mode of Delivery; metabolic syndrome
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