Natural Coumarin-Lead Compounds: A Review of Their Medicinal Potentials

Jebir, Rahma M.; Mustafa, Yasser F.

doi:10.33899/iphr.2022.170404

	Natural Coumarin-Lead Compounds: A Review of Their Medicinal Potentials
Iraqi Journal of Pharmacy
Article 12, Volume 18, Issue 2, 2021, Pages 139-161 PDF (1.17 M)
Document Type: Review Paper
DOI: 10.33899/iphr.2022.170404
Authors
Rahma M. Jebir; Yasser F. Mustafa^*
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.
Abstract
Background: Natural coumarins group, a principal member of the benzopyrone family, is one of the naturally occurring substances obtained ordinarily from plant origins, with antibacterial, anticoagulant, antihypertensive, anticancer, antioxidant, anti-inflammatory, and many other medicinal potentials. Because coumarins are found in nuts, seeds, fruits, vegetables, tea, coffee, and wine, the average person consumes a significant amount of these substances daily. Given the documented limited toxicity, relatively cheap, availability in foods, and prevalence of coumarins in numerous herbal medicines, it seems reasonable to investigate their characteristics and usage. Objective: This review discusses naturally occurring coumarin lead substances, their extensive medicinal benefits, and official pharmacopoeia-based detection methods. Conclusion: The medicinal potential and therapeutic uses of simple coumarins are determined by their structural substitution pattern. Because there is limited research on bioavailability for coumarins, additional research is needed to investigate the bioavailability for various coumarins, which have demonstrated good bioactivity in prior research.
Keywords
Natural Coumarins; antibacterial; Antiviral; Antihypertensive; Anticonvulsant

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