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SYNTHESIS AND EVOLUTION OF SULFAMETHOXAZOLE DERIVATIVE AND ASSAY ANTIBACTERIAL ACTIVITY | ||
| Basrah Journal of Veterinary Research | ||
| Article 1, Volume 20, Issue 1, 2021, Pages 1-7 PDF (1.46 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bvetr.2021.170495 | ||
| Authors | ||
| Wasfi Al-Masoudi* 1; Safana Jassim2; Huda Khassaf1 | ||
| 1Department of Physiology, Pharmacology and Biochemistry; College of Veterinary medicine; University of Basra, Basra, Iraq | ||
| 2Department of Nursing, Basrah Technical Institute, Southern Technical University, Basrah, Iraq | ||
| Abstract | ||
| Condensation of Sulfamethoxazole with 3,4-dihydroxy benzaldehyde yielded Schiff base derivative in good yield. Characterization of synthesized compound detected by Infrared (IR) and 1HNMR spectroscopy via nuclear magnetic resonance 600 MHz. The synthesized compound was screened for antibacterial activity against gram positive and gram negative bacteria. A new compound exhibited potent antibacterial activity against Klebsiella pneumonia compared to Vancomycin drug, which showed no activity against this bacterium. The synthesized compound exhibited moderate activity against Escherichia coli and Staphylococcus aurous. | ||
| Keywords | ||
| Sulfamethoxazole; Assay; Infra-Red | ||
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