THE PROTECTIVE EFFECT OF N-ACETYLCYSTEINE (NAC) AGAINST OXIDATIVE STRESS ENZYME AND LIPID PROFILE FOR TOXICITY MALE RATS BY DIMETHYLNITROSAMINE

Younis Et Al.,, Mohammed Abdulhameed

doi:10.23975/bjvetr.2020.170607

	THE PROTECTIVE EFFECT OF N-ACETYLCYSTEINE (NAC) AGAINST OXIDATIVE STRESS ENZYME AND LIPID PROFILE FOR TOXICITY MALE RATS BY DIMETHYLNITROSAMINE
Basrah Journal of Veterinary Research
Article 4, Volume 19, Issue 1, 2020, Pages 47-55 PDF (177.52 K)
Document Type: Research Paper
DOI: 10.23975/bjvetr.2020.170607
Author
Mohammed Abdulhameed younis et al.,
Department of physiology and pharmacology, College of Veterinary Medicine University of Basrah, Basrah, Iraq
Abstract
The present study is conduct to evaluated the deleterious effects of administration of dimethylnitrosamine (DMN) on the some oxidative stress and lipid profile parameters of laboratory male rats (Rattus rattus), we used eighteen adult male rats randomly divided into three equal groups ( six in each). Group 1 (control) the animals treated by given oral normal saline (0.2 ml), group 2 was treated by oral dimethylnitrosamine 30 mg/kg/day, group 3 the animals were treated by oral Nacetylcysteine 300 mg/kg/day followed by dimethylnitrosamine 30 mg/kg/day. At the end of experimental period, rats were sacrificed. Blood was collected by cardiac puncture to investigate lipid profile and oxidative parameters including serum MDA, glutathione, catalase, and SOD. Results showed a significant reduction in SOD, Catalase, glutathione, and HDL, and a significant increase in MDA, LDL, total cholesterol, triglyceride, after DMN treatment, while these changes were returned to nearly normal level when they combined NAC with DMN treatment for the 30 days treatment when compared with the control group.
Keywords
DMN; Antioxidant; Lipid profile

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