The Utility of Platelets Indices and Other Blood Parameters in Gynecological Diseases

Nori, Wassan; Ibrahim Ali, Alaa; Mokram Hamed, Roaa

doi:10.33091/amj.2021.171056

	The Utility of Platelets Indices and Other Blood Parameters in Gynecological Diseases
Al- Anbar Medical Journal
Article 2, Volume 17, Issue 1, 2021, Pages 3-8 PDF (299.73 K)
Document Type: Review articles
DOI: 10.33091/amj.2021.171056
Authors
Wassan Nori^* ¹; Alaa Ibrahim Ali¹; Roaa Mokram Hamed²
¹Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah University, Baghdad, Iraq.
²The National Center of Hematology, Mustansiriyah University, Baghdad, Iraq.
Abstract
Platelets are circulating cells known for their contribution to hemostasis, coagulation, protectingthe blood vessels integrity, and wound healing. In the last decade, increasing evidence has linkedplatelets to activities beyond that. Platelets have been implicated in many physiological andpathological conditions involving immunity, inflammation, and even malignant tumors. Their rolehas been evaluated both as prognostic and diagnostic markers. Interestingly, platelets communicatewith each other through a range of cytokines and interleukins secreted by their intracellular granulesonce activated or triggered. The understanding of this sophisticated mechanism of secretion andthe genetic guidance of granule biosynthesis remained unclear. Complete blood count and itsparameters are informative and affordable diagnostic tests as they highlighted platelet counts,plateletcrit, platelet indices; mean platelet volume, and platelet distribution width. Recently,increasing evidence suggests that implementing these parameters is a useful biomarker in the field ofgynecology. Their role in obstetrics has been discussed in many studies, especially in hypertensivediseases, diabetes, abnormal fetal growth pattern, and early pregnancy loss. This review outlinesthe role of platelets and their indices in Gynecological disease
Keywords
Platelets; Mean platelet volume; Platelets distribution width; Platelet counts; Gynecological diseases

References
[1] K. R. Machlus and J. E. Italiano, "The incredible journey: From megakaryocyte development to platelet formation," J. Cell Biol., vol. 201, no. 6, pp. 785–796, 2013. [2] S. R. Patel, J. H. Hartwig, and J. E. Italiano, "The biogenesis of platelets from megakaryocyte proplatelets," J. Clin. Invest., vol. 115, no. 12, pp., 3348–3354, 2005. [3] T. Lopatina, S. Bruno, C. Tetta, N. Kalinina, M. Porta, and G. Camussi, "Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential," Cell Commun. Signal., vol. 12, no. 1, pp. 1–12, 2014. [4] R. Leblanc and O. Peyruchaud, "Metastasis: new functional implications of platelets and megakaryocytes," Blood, J. Am. Soc. Hematol., vol. 128, no. 1, pp. 24–31, 2016. [5] S. G. Chu et al., "Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis," J. Thromb. Haemost., vol. 8, no. 1, pp. 148–156, 2010. [6] N. Afsar, I. A. Afroze, H. Tahniath, and Z. Abid, "Role of mean platelet volume as an adjunct in the evaluation of acute inflammation," Ann. Pathol. Lab. Med., vol. 4, no. 4, pp. A466–A469, 2017. [7] E. M. Golebiewska and A. W. Poole, "Platelet secretion: From haemostasis to wound healing and beyond," Blood Rev., vol. 29, no. 3, pp. 153–162, 2015. [8] R. Sachdev, A. K. Tiwari, S. Goel, V. Raina, and M. Sethi, "Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other," Indian J. Pathol. Microbiol., vol. 57, no. 2, p. 231, 2014. [9] C. Beyan, K. Kaptan, and A. Ifran, "Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggegation responses in healthy volunteers," J. Thromb. Thrombolysis, vol. 22, no. 3, pp. 161–164, 2006. [10] H. T. M. Tuan, L. S. Hock, and Z. W. Abdullah, "Haemostatic parameters, platelet activation markers, and platelet indices among regular plateletpheresis donors," J. Taibah Univ. Med. Sci., vol. 13, no. 2, p. 180, 2018. [11] Z. M. Łukasik, M. Makowski, and J. S. Makowska, "From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders," Rheumatol. Int., vol. 38, no. 6, pp. 959–974, 2018. [12] H. Demirin et al., "Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study," Thromb. Res., vol. 128, no. 4, pp. 358–360, 2011. [13] B. Karagoz, A. Alacacioglu, O. Bilgi, E. Demirci, H. Ozgun, and A. A. Erikçi, "Platelet count and platelet distribution width increase in lung cancer patients," Anatol J Clin Investig, vol. 3, no. 1, pp. 32–34, 2009. [14] B. A. Ulkumen, H. G. Pala, E. Calik, and S. O. Koltan, "Platelet distribution width (PDW): A putative marker for threatened preterm labour," Pakistan J. Med. Sci., vol. 30, no. 4, p. 745, 2014. [15] J. Sikora and B. Kostka, "Blood platelets as pharmacological model," Post Biol Kom, vol. 232, pp. 561–570, 2005. [16] A. Panasiuk, “Płytki krwi w przewlekłych chorobach wątroby,” Med. Sci. Rev., vol. 11, pp. 83–86, 2011. [17] L. Twomey et al., "Platelets: From Formation to Function," in Homeostasis-An Integrated Vision, IntechOpen, 2018. [18] C. Huchon and A. Fauconnier, “Adnexal torsion: a literature review,” Eur. J. Obstet. Gynecol. Reprod. Biol., vol. 150, no. 1, pp. 8–12, 2010. [19] H. A. Al-Turki, "Fertility after oophorectomy due to torsion," Saudi Med. J., vol. 36, no. 3, p. 368, 2015. [20] L. L. Shadinger, R. F. Andreotti, and R. L. Kurian, "Preoperative sonographic and clinical characteristics as predictors of ovarian torsion," J. Ultrasound Med., vol. 27, no. 1, pp. 7–13, 2008. [21] J. Yuk, L. Y. Kim, J. Shin, D. Y. Choi, T. Y. Kim, and J. H. Lee, "A national population‐based study of the incidence of adnexal torsion in the Republic of Korea," Int. J. Gynecol. Obstet., vol. 129, no. 2, pp. 169–170, 2015. [22] K. Nizar, M. Deutsch, S. Filmer, B. Weizman, R. Beloosesky, and Z. Weiner, "Doppler studies of the ovarian venous blood flow in the diagnosis of adnexal torsion," J. Clin. Ultrasound, vol. 37, no. 8, pp. 436–439, 2009. [23] M. Toptas, I. Akkoc, Y. Savas, S. Uzman, Y. Toptas, and M. M. Can, "Novel hematologic inflammatory parameters to predict acute mesenteric ischemia," Blood Coagul. Fibrinolysis, vol. 27, no. 2, pp. 127–130, 2016. [24] J. Budzianowski, K. Pieszko, P. Burchardt, J. Rzeźniczak, and J. Hiczkiewicz, “The role of hematological indices in patients with acute coronary syndrome,” Dis. Markers, vol. 2017, 2017. [25] E. E. Tas, H. L. Keskin, E. A. Kir, G. Kilic, G. Cetinkaya, and A. F. Yavuz, "Can preoperative complete blood count parameters be used in the diagnosis of patients with adnexal torsion: a case-control study," JPMA, vol. 70, no. 1319, 2020. [26] I. Köleli, "Mean platelet volume in early diagnosis of adnexal torsion," Balkan Med. J., vol. 32, no. 4, p. 410, 2015. [27] Y. U. Budak, M. Polat, and K. Huysal, "The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review.," Biochem. medica Biochem. medica, vol. 26, no. 2, pp. 178–193, 2016. [28] L. Vizioli, S. Muscari, and A. Muscari, "The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases," Int. J. Clin. Pract., vol. 63, no. 10, pp. 1509–1515, 2009. [29] P. Noris, F. Melazzini, and C. L. Balduini, "New roles for mean platelet volume measurement in the clinical practice?," Platelets, vol. 27, no. 7, pp. 607–612, 2016. [30] M. Oylumlu et al., "The usefulness of plateletcrit to predict cardiac syndrome X in patients with normal coronary angiogram," Postępy w Kardiol. Interwencyjnej= Adv. Interv. Cardiol., vol. 11, no. 3, p. 197, 2015. [31] M. Ergelen and H. Uyarel, "Plateletcrit: a novel prognostic marker for acute coronary syndrome," Int. J. Cardiol., vol. 177, no. 1, p. 161, 2014. [32] A. Yuri Gasparyan, L. Ayvazyan, D. P Mikhailidis, and G. D Kitas, "Mean platelet volume: a link between thrombosis and inflammation?," Curr. Pharm. Des., vol. 17, no. 1, pp. 47–58, 2011. [33] S. M. Khan, S. H. Emile, Z. Wang, and M. A. Agha, "Diagnostic accuracy of hematological parameters in Acute mesenteric ischemia-A systematic review," Int. J. Surg., vol. 66, pp. 18–27, 2019. [34] F. Sadeghi, S. Kovács, K. S. Zsóri, Z. Csiki, Z. Bereczky, and A. H. Shemirani, "Platelet count and mean volume in acute stroke: a systematic review and meta-analysis," Platelets, vol. 31, no. 6, pp. 731–739, 2020. [35] F. Eskicioglu, G. A. Turan, and E. B. Gur, "The efficacy of platelet activation indicators for the diagnosis of tubal ectopic pregnancy," Pak. J. Med. Sci. Q., vol. 31, no. 3, p. 745, 2015. [36] H. Akkaya and G. Uysal, "Can hematologic parameters predict treatment of ectopic pregnancy?," Pakistan J. Med. Sci., vol. 33, no. 4, p. 937, 2017. [37] J. Cartwright, W. C. Duncan, H. O. D. Critchley, and A. W. Horne, "Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities," Reproduction, vol. 138, no. 1, p. 9, 2009. [38] J. Kumakiri, R. Ozaki, S. Takeda, A. Malvasi, and A. Tinelli, "Tubal Pregnancy," in Management and Therapy of Early Pregnancy Complications. Springer, Cham, pp. 69–104, 2016. [39] N. Sarı, H. Işık, H. Başar, A. Seven, and A. Bostancı, "The Role of Beta-hCG Progesterone and Creatine Kinase in the Early Diagnosis of Ectopic Pregnancies," Gynecol. Obstet. Reprod. Med., vol. 19, no. 3, pp. 133–138, 2016. [40] E. Vagdatli, E. Gounari, E. Lazaridou, E. Katsibourlia, F. Tsikopoulou, and I. Labrianou, "Platelet distribution width: a simple, practical and specific marker of activation of coagulation," Hippokratia, vol. 14, no. 1, p. 28, 2010. [41] B. A. Ulkumen, H. G. Pala, E. Calik, and S. O. Koltan, "Can mean platelet volume and platelet distribution width be possible markers for ectopic pregnancy and tubal rupture? (MPV and PDW in ectopic pregnancy)," Pakistan J. Med. Sci., vol. 30, no. 2, p. 352, 2014. [42] A. Turgut, M. E. Sak, A. Ozier, H. E. Soydinc, T. Karacor, and T. Gul, "Alteration of peripheral blood cells in tubal ectopic pregnancy," Ginekol. Pol., vol. 84, no. 3, 2013. [43] A. Altieri, S. Franceschi, J. Ferlay, J. Smith, and C. La Vecchia, "Epidemiology and etiology of gestational trophoblastic diseases," Lancet Oncol., vol. 4, no. 11, pp. 670–678, 2003. [44] Y. Shen, X. Wan, and X. Xie, "A metastatic invasive mole arising from iatrogenic uterus perforation," BMC Cancer, vol. 17, no. 1, pp. 1–4, 2017. [45] C. Lok et al., "Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease," Eur. J. Cancer, vol. 130, pp. 228–240, 2020. [46] R. Monchek and S. Wiedaseck, "Gestational trophoblastic disease: an overview," J. Midwifery Women's Heal., vol. 57, no. 3, pp. 255–259, 2012. [47] L. Zhang, Y. Xie, and L. Zhan, "The potential value of red blood cell distribution width in patients with invasive hydatidiform mole," J. Clin. Lab. Anal., vol. 33, no. 4, p. e22846, 2019. [48] E. Karsten, E. Breen, and B. R. Herbert, "Red blood cells are dynamic reservoirs of cytokines," Sci. Rep., vol. 8, no. 1, pp. 1–12, 2018. [49] G. Landskron, M. De la Fuente, P. Thuwajit, C. Thuwajit, and M. A. Hermoso, "Chronic inflammation and cytokines in the tumor microenvironment," J. Immunol. Res., vol. 2014, 2014. [50] R. Roshani, F. McCarthy, and T. Hagemann, "Inflammatory cytokines in human pancreatic cancer," Cancer Lett., vol. 345, no. 2, pp. 157–163, 2014. [51] S. Hunziker, L. A. Celi, J. Lee, and M. D. Howell, "Red cell distribution width improves the simplified acute physiology score for risk prediction in unselected critically ill patients," Crit. care, vol. 16, no. 3, pp. 1–8, 2012. [52] H. Alcaino, J. Pozo, M. Pavez, and H. Toledo, "Red cell distribution width as a risk marker in patients with cardiovascular diseases," Rev. Med. Chil., vol. 144, no. 5, pp. 634–642, 2016. [53] L. M. Leader A, Pereg D, "Are platelet volume indices of clinical use? A multidisciplinary review," Ann. Med., vol. 44, no. 8, pp. 805–816, 2012. [54] K. Walch et al., "Implanon® versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis—a pilot study," Contraception, vol. 79, no. 1, pp. 29–34, 2009. [55] P. Vercellini, P. Viganò, E. Somigliana, and L. Fedele, “Endometriosis: pathogenesis and treatment,” Nat. Rev. Endocrinol., vol. 10, no. 5, p. 261, 2014. [56] M. Moradi, M. Parker, A. Sneddon, V. Lopez, and D. Ellwood, "Impact of endometriosis on women's lives: a qualitative study," BMC Women's. Health, vol. 14, no. 1, p. 123, 2014. [57] W.-J. Zhou et al., "Anti-inflammatory cytokines in endometriosis," Cell. Mol. Life Sci., vol. 76, no. 11, pp. 2111–2132, 2019. [58] K. Young, J. Fisher, and M. Kirkman, "Women's experiences of endometriosis: a systematic review and synthesis of qualitative research," J. Fam. Plan. Reprod. Heal. Care, vol. 41, no. 3, pp. 225–234, 2015. [59] P. A. W. Rogers et al., "Research priorities for endometriosis: recommendations from a global consortium of investigators in endometriosis," Reprod. Sci., vol. 24, no. 2, pp. 202–226, 2017. [60] M. Canis et al., "Revised American society for reproductive medicine classification of endometriosis: 1996," Fertil. Steril., vol. 67, no. 5, pp. 817–821, 1997. [61] N. Leyland et al., “Endometriosis: diagnosis and management,” J. Endometr., vol. 2, no. 3, pp. 107–134, 2010. [62] K. L. L. Habets, T. W. J. Huizinga, and R. E. M. Toes, "Platelets and autoimmunity," Eur. J. Clin. Invest., vol. 43, no. 7, pp. 746–757, 2013. [63] H. Miyazaki and T. Kato, "Thrombopoietin: biology and clinical potentials.," Int. J. Hematol., vol. 70, no. 4, pp. 216–225, 1999. [64] I. Santimone et al., "White blood cell count, sex and age are major determinants of the heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project," Haematologica, vol. 96, no. 8, pp. 1180–1188, 2011. [65] M. Mendonça Carneiro, I. D. de Sousa Filogônio, L. M. Pyramo Costa, I. de Ávila, and M. C. França Ferreira, "Clinical prediction of deeply infiltrating endometriosis before surgery: is it feasible? A review of the literature," Biomed Res. Int., vol. 2013, 2013. [66] B. Seckin, M. C. Ates, A. Kirbas, and H. Yesilyurt, "Usefulness of hematological parameters for differential diagnosis of endometriomas in adolescents/young adults and older women," Int. J. Adolesc. Med. Health, vol. 1, no. ahead-of-print, 2018. [67] S. N. Avcioğlu, S. Ö. Altinkaya, M. Küçük, S. Demircan-Sezer, and H. Yüksel, “Can platelet indices be new biomarkers for severe endometriosis?,” Int. Sch. Res. Not., vol. 2014, 2014. [68] M. Leonardi et al., "Transvaginal ultrasound can accurately predict the American Society of Reproductive Medicine (ASRM) stage of endometriosis assigned at laparoscopy," J. Minim. Invasive Gynecol., Vol. 27, no. 7, pp. 1581-1587, 2020. [69] A. Turgut, M. Hocaoğlu, O. I. Özdamar, U. Akın, T. Günay, and E. Akdeniz, "Could hematologic parameters be useful biomarkers for the diagnosis of endometriosis?" Bratisl. Med. J., vol 120, pp. 912–918,2019. [70] B. Coskun et al., "The feasibility of the platelet count and mean platelet volume as markers of endometriosis and adenomyosis: A case-control study," J. Gynecol. Obstet. Hum. Reprod., vol. 49, no. 10, p. 101626, 2020. [71] C. B. Thompson, "From precursor to product: how do megakaryocytes produce platelets?," Prog. Clin. Biol. Res., vol. 215, pp. 361–371, 1986. [72] N. Cay, A. Ipek, M. Gumus, Z. Birkan, and E. Ozmen, "Platelet activity indices in patients with deep vein thrombosis," Clin. Appl. Thromb., vol. 18, no. 2, pp. 206–210, 2012. [73] R. Seki and K. Nishizawa, "Inflammatory vs. thrombotic states of platelets: a mini-review with a focus on functional dichotomy," Ann Biomed Res, vol. 1, no. 1, p. 107, 2018.
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