Tayib, S., Alkubais, H. (2018). Synthesis and Characterization of Some Compounds containing Pyrazole Moiety. , 12(1), 54-65. doi: 10.37652/juaps.2022.171558
Samer M. Tayib; Hameed M. Mohammed i Alkubais. "Synthesis and Characterization of Some Compounds containing Pyrazole Moiety". , 12, 1, 2018, 54-65. doi: 10.37652/juaps.2022.171558
Tayib, S., Alkubais, H. (2018). 'Synthesis and Characterization of Some Compounds containing Pyrazole Moiety', , 12(1), pp. 54-65. doi: 10.37652/juaps.2022.171558
Tayib, S., Alkubais, H. Synthesis and Characterization of Some Compounds containing Pyrazole Moiety. , 2018; 12(1): 54-65. doi: 10.37652/juaps.2022.171558

Synthesis and Characterization of Some Compounds containing Pyrazole Moiety

Journal of University of Anbar for Pure Science
Article 11, Volume 12, Issue 1, 2018, Pages 54-65    PDF (798.12 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2022.171558
Authors
Samer M. Tayib* 1; Hameed M. Mohammed i Alkubais2
1Department of Chemistry ,College of Science , University of Anbar
2Faculty of Medicine , University of Fallujah
Abstract
This study includes the preparation of some heterocyclic compounds compact of the Pyrazole, work is done in three steps. First step, treatment of acetophenone derivatives with DMF-DMA for the preparation of the first compound (2E)-1-( R phenyl)-3-(dimethylamino)prop-2-en-1-one , (R) is one of the derivatives used for acetophenone (R = Br, NH2 ). The second step, treatment of benzaldehyde derivatives with hydrazine to prepare the second compound in the series (1E) - (R benzylidene) hydrazine, where (R) is one of the derivatives used for benzaldehyde to get the Shiff bases. And the third step, treatment of the first step products with the products of the second step. Each product from the first step gives us a series of Pyrazole compounds with its reaction with products of the second step interaction after the other. Thus, we can bring a number of compounds, the sum of the first step products multiplied by the products of the second step. The third-step reaction is a ring-blocking reaction to form a combined heterogeneous ring of Pyrazole. Finally, characterization these compounds with infrared spectra, NMR spectrum and mass spectrometry.
Keywords
heterocyclic compounds; acetophenone derivatives; benzaldehyde; Pyrazole
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