Hilal, D., Al-Ani, M., Hamid, N. (2019). Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women. , 13(2), 1-9. doi: 10.37652/juaps.2022.171878
Daua Jameel Hilal; Mohammed Qais Al-Ani; Nuhad Mohammed Hamid. "Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women". , 13, 2, 2019, 1-9. doi: 10.37652/juaps.2022.171878
Hilal, D., Al-Ani, M., Hamid, N. (2019). 'Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women', , 13(2), pp. 1-9. doi: 10.37652/juaps.2022.171878
Hilal, D., Al-Ani, M., Hamid, N. Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women. , 2019; 13(2): 1-9. doi: 10.37652/juaps.2022.171878

Hematological and Immunological Parameters Associated with Vitamin D Deficiency in Pregnant Women

Journal of University of Anbar for Pure Science
Article 1, Volume 13, Issue 2, 2019, Pages 1-9    PDF (325.76 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2022.171878
Authors
Daua Jameel Hilal* 1; Mohammed Qais Al-Ani2; Nuhad Mohammed Hamid3
1University Of Anbar – College of Education For Women – Anbar - Iraq
2University of Anabr – College of Science – Anbar - Iraq
3Ministry Of Education – Anbar - Iraq
Abstract
The aim of the study is to follow up a number of biochemical, immunological and physiological changes associated with vitamin D deficiency in pregnant women. 50 samples were collected from pregnant women, 50 from control group and 50 from non-pregnant women. A number of laboratory tests were carried out on the withdrawn blood samples. These tests examined the ELISA to measure vitamin D concentration. The concentration of vitamin D in the pregnant women group, control group and the non-pregnant women group (26.31,43.97,50.9) were found to be Nano mole / L respectively, indicating a decrease in vitamin D concentration in pregnant women compared to the control group. The results of the present study showed a significant decrease in the volume of the red blood cells in the three studied groups at the probability level P  

 
Keywords
Vitamin D deficiency; Complete Blood Count; IgE; CRP
References
  1. Garland C, Gorham E, Mohr S, et al. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol 2007;103:708–11.
  2. Holick MF. (2004) Sunlight and vitamin D for bone health and  prevention of autoimmune diseases, cancers, and cardiovasculardisease. Am J Clin Nutr. 2004;80(6 Suppl):1678S-88S. doi: 10.1093/ajcn/80.6.1678S.                                                          
  3. Knutsen KV, Brekke M, Gjelstad S, et al.(2010). "Vitamin D status in patients with musculoskeletal pain, fatigue and headache: a cross-sectional descriptive study in a multi-ethnic general practice in Norway." Scandinavian journal of primary health care. 2010;28(3): 166-71
  4. Sharma D, Saxena R, Saxena R, et al. Systemic inflammation and alteration in vitamin D levels in pregnancy induced hypertension. ASIAN JOURNAL OF MEDICAL SCIENCES. 2014; 5(4):11-15.                                                 
  5. Kulie T, Groff A, Redmer J, et al. Vitamin D: An Evidence-Based Review. J Am Board Fam Med. 2009; 22:698-706.
  6. Jani R, Palekar S, Munipally T, et al. Widespread 25-Hydroxyvitamin D Deficiency In Affluent And Non-affluent Pregnant Indian Women. Biomed Res Int. 2014; 2014: 892162. doi: 10.1155/2014/892162.                                                   
  7. Urrutia RP, Thorp JM. Vitamin D in pregnancy: Current concepts. Curr. Opin. Obstet. Gynecol. 2012;24:57–64. doi: 10.1097/GCO.0b013e3283505ab3.
  8. Aghajafari F, Nagulesapillai T, Ronksley PE, et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of observational studies. BMJ. 2013; 26:346:f1169. doi: 10.1136/bmj.f1169.
  9. Sood R. Practical pathology and microbiology. Jaypee Brothers.1989; NewDelhi.India.
  10. Halmet J.(1967):International committee for standardization in haematology.13(suppl:71.
  11. International committee for standardization in haematology. Recommendations for haemoglobinometry in human blood. Br J Haematol. 1967; 13:71-5.
  12. Okoroiwu  I L, Ifeayi OE, Uzoma OG, Doris A. The Relationship between  platelet  Count and Haemoglobin Level.Sch.  Acad.J. Biosci.2015;3(8):66-68.                                                                
  13. Urrutia-Pereiraa M, Solé D. Vitamin D deficiency in pregnancy and its impact  on the fetus, the newborn and in childhood. REVISTA PAULISTA DE PEDIATRIA. 2015; 33(1):104-113.
  14. Gür G,  Abaci A, Köksoy AY, et al . Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study. Turkish Journal of Medical Sciences. 2014; 44: 616-623.
  15. Özdemir AA,  Gündemir YE, Küçük MS, et al. Vitamin D Deficiency in Pregnant Women and Their Infants . J Clin Res Pediatr Endocrinol. 2018;10(1):44-50.
  16. Alfaham S, Datta M, Dunstan  DP, et al.(2002). Vitamin D deficiency in pregnant women from a non-European ethnic minority population—an interventional study. International Journal of Obstetrics and Gynaecology. 2002; 109: 905–908.                                                                 
  17. Sahu M, Bhati V, Aggarwal A, et al. Blackwell Publishing Ltd Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India. Clinical Endocrinology. 2009; 70: 680–684
  18. Singh P.(2018). Treatment of Vitamin D Deficiency and Comorbidities: A Review. Journal of The Association of Physicians of India. 2018; 66:75-82.                                                                                   
  19. Haroon M, Fitzgerald O. Vitamin D and its emerging role in immunopathology. Clin Rheumatol. 2012; 31 (2): 199–202.                                                                 
  20. Marwah S, Walls A, Blann AD. Relationship between vitamin D and red blood cell indices in South Asians and White Europeans. British Journal of Biomedical Science. 2012; 69 (4) :1-3.                                                                                                                                                                                  
  21. Sim J, Loc P, Lui I. Vitamin D deficiency and anemia: across-sectional study.Ann.Hematol. 2010;89(5):447-452.
  22. Yuan  Y, Cai Z, Dai Y, et al. Association of Maternal Serum 25-Hydroxyvitamin D Concentrations with Risk of Gestational Anemia. Cell Physiol Biochem. 2017; 43:1526-1532.                                                                 
  23. Skjelbakken T, Wilsgaard T, Førde OH. Haemoglobin predicts total mortality in a general young and middle-aged male population. The Tromsø Study. Scand J Clin Lab Invest. 2006;66(7):567–576.
  24. Zhu T, Liu T, Ge X, et al. High prevalence of maternal vitamin D deficiency in  preterm births in northeast China, Shenyang . Int J Clin Exp Pathol; 2015;8(2):1459-1465.
  25. Malczewska-Lenczowska J, Sitkowski D, Surała O, et al. The association between Iron and vitamin D status  in female elite Athletes. Nutrients. 2018;31;10(2). pii: E167. doi: 10.3390/nu10020167.
  26. Gur EB, Karadeniz M, Genc M, et al. Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus. Arch Endocrinol Metab. 2015; 1-7.                    
  27. Wagner CL, Taylor SN, Dawodu A, et al. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients. 2012; 4(3): 208-230.
  28. Akbas EM, Gungor A, Ozcicek A, et al. Vitamin D and inflammation: evaluation with neutrophil- to-lymphocyte ratio and platelet-to-lymphocyte ratio. Arch Med Sci. 2016;4:721-727.                                          
  29. Amer A Qayyum R. Relationship between serum  25-hydroxy vitamin D and C-reactive protein  in  a symptomatic  adults .Am.J.Cardiol. 2013;109:226-230.                                                                         
  30. Kim S, Kwon HS, Hwang H. White blood  cell counts ,insulin resistance, vitamin D levels and sarcopenia  in Korean  elderly  men. Scand J clin lab invest. 2017; 77(3): 228-233.
  31. Perez-Lopez FR, Pasupuleti V, Mezones-Holguin E, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015;103(5):1278-88.e4.
  32. Tulic M. Vitamin D  in pregnancy and early life .Expert Rev Clin Immunol. 2013; 9(9):817-820.
  33. Bahna S, Woo K, Manuel P, Guarderas J. Serum Total IgE during pregnancy  and Postpartum Allergol .immunopathol.2011;39(5):291-304.
  34. Lui N, Kaplan A, Low J, Hewison M. Vitamin D induces innate  antimicrobial responces human trophblast  via intracrine  pathway. Biol .Reprod. 2009;80:398-406.
  35. Manousaki D, Patemoster L, Richard B. Vitamin D levels and Susceptibility to Asthma elevated  IgE levels  and  atopic  dermatisis:Amendelian  randomization study. PLoS Medicine. 2017;14(5):e1002294,1-16. 
  36. [36] Myburgh PH, Towers G, Wayne K, et al. CRP Genotypes Predict Increased Risk to Co-Present with Low Vitamin D and Elevated CRP in a Group of Healthy Black South African Women. Int. J. Environ. Res. Public Health. 2018; 15( 111):1-16.                                                                        
  37. Dabbah H, Yoseph RB, Livnat G, et al. Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma. Respiratory Care. 2015; 60(8):1157-1163.                                                
  38. Pourghassem GB, Pourteymour FTF, Sadien B, et al. Vitamin D Status Is Related to Oxidative Stress But Not High-Sensitive C-Reactive Protein in Women with Pre-Eclampsia. Gynecol Obstet Invest. 2016;81(4):308-14.                                                                                        
  39. Ledue TB, Rifai N. Preanalytical and analytical Sources of Variations in C-reactive proteins  measurment :Implications for Cardiova-scula-disease  risk assessment. Clin.Chem. 2003; 49(8):1258-1271.                                                                      
  40. Gutaj P, Kryzanowska P, Ozegowska E. Determinant of C-reactive protein Coneentration in Pregnant women with type 1 diabetes. Pol Arch Med Women. 2016; 13;126(4):230-236.                                                                                                                                                       
  41. Jorde R, Senev M, Torjesen P. No effect of supplementation with cholecalciferol on cytokine and markers of inflammation in overwight and obese subjects. Cytokine. 2010;50(2):175-180.                                                                                                                     
  42. Ridker M, Danielson E, Fonseca F. Jupiter Study Group Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195-2207.                      
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