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Alcohol extract of Tribulus terrestris ameliorates liver of mice exposed to cadmium acetate | ||
| Journal of University of Anbar for Pure Science | ||
| Article 2, Volume 13, Issue 2, 2019, Pages 10-15 PDF (550.36 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2022.171881 | ||
| Author | ||
| Ahmed Sami Farhan* | ||
| Department of Biology / college of Science / University Of Anbar / Anbar- Iraq. | ||
| Abstract | ||
| Background: Tribulus terrestris is known as food supplements and therapeutic agent. Objective: This study was presented to evaluate antitoxicity of fruit alcohol extracted from Tribulus terrestris to be used against heavy metal (cadmium) in female of albino mice. Methods: Twenty mice were examined in this experiment, and they were divided into three groups. The first group was a control group, while the second group was quaffed cadmium 6mg/kg, and third group was quaffed cadmium 6mg/kg and fruit alcohol extract of Tribulus terrestris 200mg/kg for ten days. Histological change was studied in the livers of these mice.Results: The histological sections of the liver in the mice exposed to cadmium have shown inflammation and necrosis in hepatocytes around central vein. Moreover, the liver was also hypertrophy, karyomegaly and increases glycogenesis. The results of the cadmium-exposed mice treated with the extract of Tribulus terrestris showed that the damage in the liver was slight. It showed normal cell shape and hepatic plate. It also showed simple inflammation and hypertrophy in a small space. Conclusion: The fruits of Tribulus terrestris can remove toxicity, protect our bodies (especially liver) against heavy metal such as cadmium. | ||
| Keywords | ||
| Tribulus terrestris; cadmium toxicity; hepatic tissue; mice | ||
| References | ||
|
1. Bernhoft R. A. (2013). Cadmium toxicity and treatment. The Scientific World Journal. 1-7.
2. Sharma, H.; Rawal, N. and Mathew, B. B. (2015). the characteristic, toxicity and effects of cadmium. International Journal of Nanotechnology and Nanoscience. 3: 1-9.
3. Kowalewska, R. S. (2001). Cadmium distribution and toxicity in tissues of small rodents. Microscopy Research and Technique. 55:208–222.
4. Mokhtar, G.; Hossny, E.; El-Awady, M. and Zekry, M. (2002). In utero exposure to cadmium pollution in Cairo and Giza governorates of Egypt. East Medical. Health Journal. 8(2): 1-6.
5. Zalups, P. and Ahmed, S., (2003). Molecular handling of cadmium in transporting epithelia. Toxicology Application Pharmacology 1; 186(3): 163-188.
6. Karimi, M. M.; Sani, M. J.; Mahmudabadi, A. Z.; Sani, A. J. and Khatibi, S. R. (2012). Effect of Acute Toxicity of Cadmium in Mice Kidney Cells. Iranian Journal of Toxicology. 6 (18): 691-698.
7. Nemmiche, S. (2017). Oxidative Signaling Response to Cadmium Exposure. Toxicological sciences. 156 (1): 4–10.
8. Miraj, S. (2016). Tribulus terrestris: Chemistry and pharmacological properties. Der Pharma Chemica Journal. 8(17):142-147.
9. Hussain, A. A.; Mohammed, A. A.; Ibrahim, H. H. and Abbas, A. H. (2009). Study the Biological Activities of Tribulus Terrestris Extracts. International Journal of Chemical and Molecular Engineering. 3(9): 510-512.
10. Abdel-Kader, M. S.; Al-Qutaym, A.; Bin Saeedan, A. S.; Hamad, A. M. and Alkharfy, K. M. (2016). Nephroprotective and hepatoprotective effects of Tribulus terrestris L. growing in Saudi Arabia. Journal of Pharmacy & Pharmacognosy Research, 4 (4): 144-152.
11. Kumar, P. and Singh, P. (2016). tribulus terrestris ameliorates aluminum-chloride induced alterations in oxidative status and functional marker in the liver, kidney, brain and testis of the laboratory mouse. Indian Journal of biochemistry and biophysics. 53: 179-186.
12. Pandey, R.; Shankar, B. S. and Sainis, K. B. (2007) Tribulus terrestris Fruit Extract Protects Against Oxidative Stress-Induced Apoptosis. Pharmaceutical Biology. 45(8): 619–625.
13. Kumar, M.; Soni, A. K.; Shukla, S. and Kumar, A. (2006). Chemopreventive potential of Tribulus terrestris against 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice. Asian Pacific Journal Cancer Prevention. 7: 289–294.
14. Kafeel, H. and Rukh, R. (2015). Anxiolytic activity of ethanolic extract of aerial parts of Tribulus terrestris in mice. The Journal of Phytopharmacology. 4(1): 17-21.
15. Ibrahim, N. M. and Kadhim, E. J. (2015). Phytochemical Investigation and Antioxidant Activity of Iraqi Tribulus terrestris. Iraqi J Pharm Sci. 24(1): 68-73.
16. Chhatre, S.; Nesari, T.; Somani, G.; Kanchan, D. and Sathaye, S. (2014). Phytopharmacological overview of Tribulus terrestris. Pharmacognosy Reviews. 8:45-51.
17. Heidari, M. R.; Mehrabani, M.; Pardakhty, A.; Khazaeli, P.; Zahedi, M. J.; Yakhchali, M. and Vahedian, M. (2007). The Analgesic Effect of Tribulus terrestris Extract and Comparison of Gastric Ulcerogenicity of the Extract with Indomethacine in Animal Experiments. Annals of the New York Academy of Sciences. 1095: 418-427.
18. Ibrahim, M. A.; Almaeen, A. H.; Abd El Moneim, M.; Tammam, H. G.; Khalifa, A. M. and Nasibe, M. N. (2018). Cadmium‑induced Hematological, Renal, and Hepatic Toxicity: The Amelioration by Spirulina platensis. The Saudi Journal of Forensic Medicine and Sciences. 1:5-13.
19. Nessa, F. and Khan S. A. (2015). Evaluation of Free Radical Scavenging Activity and Toxic Heavy Metal Contents of Commercially Available Fruits of Tribulus terrestris Linn. European Journal of Medicinal Plants. 9(3): 1-14.
20. Abid-Al-Amer, H. A. and Abdullah, B. N. (2006). Effect of cadmium chloride in drinking water on liver and kidneys function in rats. Al-Qadisiyah Journal of Veterinary Medicine Sciences. 5(2): 91-103.
21. Rajendar, B.; Bharavi, K.; Rao, G. S.; Kishore, P.V.S.; Kumar, P. R.; Kumar, C.S.V. S. and Patel, T. P. (2011). Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage. Indian Journal of Pharmacology. 43(5): 568–573.
22. Lakshmi, G.D.; Kumar, P.R.; Bharavi, K.; Annapurna, P.; Rajendar, B.; Patel, P.T.; Kumar, C.S.V. S. and Rao, G.S. (2013). Protective effect of Tribulus terrestris linn on liver and kidney in cadmium intoxicated rats. Indian Journal of | ||
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