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STUDY EFFECT THE DEXAMETHASONE FOR LONG TERM IN EYE RABBITS | ||
| Basrah Journal of Veterinary Research | ||
| Article 1, Volume 14, Issue 2, 2015, Pages 1-8 PDF (1.51 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvetr.1970.172810 | ||
| Author | ||
| Rana K. Abdulsamad* | ||
| Abstract | ||
| To study the effect of over dosages of dexamethasone on eye rabbits; a total of 20 healthy adult rabbits were used. Rabbits were equally divided in to 4 groups, the rabbit in each group wastreated with dexamethasone intramuscular twice daily for 30 days. The dexamethasone doses were10, 20, 30, and 40 mg/kg/day, for group 1, 2, 3, and 4 respectively. After that the animals were sacrificed, histological sections of cornea samples were prepared using hematoxylin and eosin staining. The entire experiment was completed in the animal facility at Veterinary Medicine College, University of Basrah. Rabbits in Group 1 and 2 remain healthy and there are no side effects of dexamethasone while group 3 and 4 the side effects of dexamethasone were cataract and emaciation. The cataract was clear clinically and histologically. The development of dexamethasone-induced cataract need much work to elucidate the mechanism | ||
| Keywords | ||
| Dexamethasone; Glucocorticoids; Rabbits | ||
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