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Salivary and serum immune system in relation to caries-experience among type 1 insulin-dependent diabetic children | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 22, Issue 2, 2010, Pages 108-112 | ||
| Authors | ||
| Sulafa El-Samarrai; Nadia Al-Rawi | ||
| Abstract | ||
| ABSTRACTBackground: Diabetes mellitus is a metabolic disorder of multiple etiology, effects of the disease include long-termdamage, dysfunction and failure of various organs in addition to oral complications.Aims of this study: These were to investigate the severity of dental caries in relation to salivary and serum immunesystem (IgA, IgG, IgM), tumor necrosis factor–a (TNF-a) and interlukin–6 (IL-6) in addition to salivary peroxidaseenzyme among type 1 insulin dependent diabetic children.Patients and methods: The study group included 60 children, with an age range of 11-13 years of both sexes. Theywere with confirmed diagnosis of type 1 insulin dependent diabetes mellitus. Children were divided into two groupsaccording to the duration of the disease. The control group included 30 children matching with an age and genderwith the two study groups. Assessment and recording of caries – experience were through the application ofdecayed, missing and filled surface index (DMFS&dmfs). The collection of stimulated salivary samples was performedunder standardized condition. Salivary and serum samples were chemically analyzed for detection of immunesystem.Results: A high severity of dental caries was seen among diabetic group compared to the control, differences werestatistically highly significant in permanent dentition. High mean values were recorded concerning salivary IgA, IL-6and TNF-a among the long duration diabetic group with statistically highly significant difference between groups inIgA & IL-6, while IgM showed the highest mean value in saliva of the control group, differences were highly significantbetween the examined groups. A highest mean value in salivary peroxidase was recorded among the newlydiagnosed diabetic. Statistically significant differences were seen in serum IgA & IgM between different groups.Conclusions: Increase values of salivary and serum immune factors recorded among diabetic children compared tohealthy.Key words: Diabetes mellitus, immune system, cytokines, dental caries. (J Bagh Coll Dentistry 2010;22(2):108-112). | ||
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