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DETERMINATION OF LD50 AND ACUTE TOXICITY EFFECTS ON SOME BIOCHEMICAL PARAMETERS INDUCED BY AMITRAZ IN RATS | ||
| Basrah Journal of Veterinary Research | ||
| Article 11, Volume 18, Issue 2, 2019, Pages 344-358 PDF (352.95 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvetr.2022.174169 | ||
| Authors | ||
| Mahmood B. Mahmood* ; Zainab T. Mohammed | ||
| Abstract | ||
| The aim of the study is determine the toxic effects and some biochemical changes of amitraz insecticide in adult albino female rats. First the median lethal dose ( ) of oral amitraz was (717.125mg/kg)and were clear toxic signs of amitraz intoxication such as incoordination, dull, depression, salivation, bulging of eyes, recumbence and death. Then alpha 2 (α-2) adrenoceptor antagonist atipamezole at (0.5 and 1mg/kg), and alkalinizing agents sodium bicarbonate at (50 and 100 mg/kg) were given by IP route, 15minutes before giving the oral administration of amitraz improved the prophylactic rates to 14.66 % and 24.45% for atepamizole, and to1.79 % and 17.38% for Sodium bicarbonate respectively, and the toxic signs of amitraz intoxication were reduced when atipamezole and sodium bicarbonate injected. After three hours of oral non-lethal amitraz dosing with (250 and 500mg/kg) increased serum glucose concentration (291.33±2.9 and 328.02±4.8mg/dL) respectively compared with the control group value (134.05±9.6 mg/dL), also the Amitraz at same doses were risen up the level of serum cortisol to (7.30±0.3 and 7.43±0.3 µg/dL) respectively as compared with the control value (2.39±0.26 µg/dL). Also it causes an increased serum level of transaminases enzymes (AST and ALT) compared with the control value, while amitraz at (500mg/kg, orally) increased enzyme ALP activity in the serum of rats when it is compared with control value. The results of this study refer to that amitraz may cause tissues damage and toxic effects in rats. | ||
| Keywords | ||
| Amitraz; ALT; ALP; Rat | ||
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