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Antichlamydial Antibodies In Women With Ectopic Pregnancy | ||
| Kirkuk Journal of Medical Sciences | ||
| Article 7, Volume 10, Issue 1, 2022, Pages 105-118 PDF (647.15 K) | ||
| Document Type: Original research | ||
| DOI: 10.32894/kjms.2022.174201 | ||
| Authors | ||
| Sahar Kamak Jalal* 1; Ayla Khedher Ghalib2 | ||
| 1MB CH B, Iraqi Board for Medical Specialization, Iraq | ||
| 2Department of Obstetrics and Gynecology, College of Medicine, University of Kirkuk, Kirkuk, Iraq | ||
| Abstract | ||
| Background: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection globally and is associated with serious reproductive complications, including ectopic pregnancy. The presence of anti-chlamydial immunoglobulin G (IgG) antibodies has been linked to a higher risk of ectopic pregnancy. This study aimed to compare the frequency of Chlamydia trachomatis infection in women with ectopic pregnancy versus those with normal intrauterine pregnancies. Methods: A case-control study was conducted over 10 months (February–December 2019) at the Department of Obstetrics and Gynecology, Azadi Teaching Hospital, Kirkuk, Iraq. A total of 86 pregnant women were enrolled: 43 with confirmed ectopic pregnancy (case group) and 43 with early normal intrauterine pregnancies (control group). Women with a history of ectopic pregnancy, infertility, tubal surgery, smoking, or intrauterine device use were excluded. Serum anti-chlamydial IgG titers were measured in all participants. Result: There were no statistically significant differences between the groups regarding age, gestational age, body mass index, or parity. Anti-chlamydial IgG was positive in 39.5% of women with ectopic pregnancy compared to 16.3% in the control group. The mean antibody titer was significantly higher in the ectopic pregnancy group. A titer above 9.98 NTU may predict the risk of ectopic pregnancy. No significant correlations were found between antibody titer and demographic or clinical parameters. Conclusions: A higher frequency and titer of anti-chlamydial antibodies were observed in women with ectopic pregnancy. These findings suggest a potential role of chlamydial infection in the pathogenesis of ectopic pregnancy. | ||
| Keywords | ||
| Ectopic pregnancy; Chlamydia trachomatis; Anti-chlamydial IgG antibodies | ||
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