Hussein, S., Alzubaidi, A. (2021). Risk Factors and Clinicopathological Characteristics among Patients with Gastric Cancer in Oncology Teaching Hospital. , 21(2), 190-195. doi: 10.52573/ipmj.2021.174630
Sherin Ali Hussein; Azher Sabeh Alzubaidi. "Risk Factors and Clinicopathological Characteristics among Patients with Gastric Cancer in Oncology Teaching Hospital". , 21, 2, 2021, 190-195. doi: 10.52573/ipmj.2021.174630
Hussein, S., Alzubaidi, A. (2021). 'Risk Factors and Clinicopathological Characteristics among Patients with Gastric Cancer in Oncology Teaching Hospital', , 21(2), pp. 190-195. doi: 10.52573/ipmj.2021.174630
Hussein, S., Alzubaidi, A. Risk Factors and Clinicopathological Characteristics among Patients with Gastric Cancer in Oncology Teaching Hospital. , 2021; 21(2): 190-195. doi: 10.52573/ipmj.2021.174630

Risk Factors and Clinicopathological Characteristics among Patients with Gastric Cancer in Oncology Teaching Hospital

Iraqi Postgraduate Medical Journal
Article 11, Volume 21, Issue 2, 2022, Pages 190-195    PDF (183.86 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2021.174630
Authors
Sherin Ali Hussein1; Azher Sabeh Alzubaidi2
1Oncology Department, Al-Yarmouk Teaching Hospital, Baghdad-Iraq
2Baghdad Teaching Hospital, Baghdad, Iraq
Abstract
BACKGROUND:
Gastric cancer is a rare tumor and one of the leading causes of death worldwide, unfortunately most of patient present late. 
PATIENTS AND METHODS:
Case -control study conducted on patients affected with gastric cancer presented to oncology teaching hospital. Data regarding their family history of gastric cancer, smoking and blood group were collected for patients and for participants in Control group matching in respect to age, sex, number and geographical area.          
OBJECTIVE:
Assess the most important risk factors of gastric cancer  Assess clinicpathologic and their histological subtypes
RESULT:
77 patients with stomach cancer and 77 control participants their age range from 27 up to 74. Mean age (SD) of (54 ± 13.8 and 55.1 ±13 years) respectively. A significant association between smoking and gastric cancer (62.3%) of index group compared to (39%) in control   (p=0.002). also a significant association between First degree family history of stomach cancer was found in 11.7% in index group compared to (0%) in control (p= 0.001). The most frequent site for cancer was antrum 31.1% of cases. diffuse subtype of adenocarcinoma(50.6%). Stage IV formed the majority of patients (62.4%).
CONCLUSION:
Smoking and family history of first degree relative have strong association with gastric cancer. Majority of patients present at advanced stage 4 and diffuse type of adenocarcinoma. Antrum is the most affected part of the stomach.
 
Keywords
Gastric cancer; Histology subtypes
References
  1. Siegel RL, Miller KD, Jemal A. Cancer statistic, 2018. CA Cancer J Clin 2018;68(1):7_30.
  2. Manish A. Shah, MD, ASCO-SEP MEDICAL ONCOLOGY SELF-EVALUATION PROGRAM, Martee L.Hensley, 2018; 6th ed:554.
  3. Anderson WF, Camargo MC, Fraumeni JF Jr, et al. Age-specific trends in incidence of noncardia gastric cancer in US adults. JAMA 2010; 303:1723–28.
  4. Chia NY, Tan P. Molecular classification of gastric cancer. Ann Oncol 2016;27:763–69.
  5. Roy P, Piard F, Dusserre‐Guion L, Martin L, Michiels‐Marzais D, Faivre J. Prognostic comparison of the pathological classifications of gastric cancer: a population‐based study. Histopathology. 1998 ;33:304-10.
  6. Dixon MF, Martin IG, Sue‐Ling HM, Wyatt JI, Quirke P, Johnston D. Goseki grading in gastric cancer: comparison with existing systems of grading and its reproducibility. Histopathology. 1994 ;25:309-16.
  7. PAGNINI CA, Rugge M. Gastric cancer: problems in histological diagnosis. Histopathology. 1982 ;6:391-98.
  8. Laurén P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31–49.
  9. Bartosz Chmielowski, Mary Territo. Manual of Clinical Oncology. 8th ed: Wolters Kluwer; 2017. Chapter 10: 337-427.
10. Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 1980;69:491–97.

11. Moon JS. Screening upper endoscopy for early detection of gastric cancer. J Korean Med Sci 2018;33:e190.

12. Dassen AE, Lips DJ, Hoekstra CJ, Pruijt  JF, Bosscha K. FDG-PET has no definite role in preoperative imaging in gastric cancer. Eur J Surg Oncol 2009;35:494-55. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19147324.

13. Balakrishnan M, George R, Sharma A, Graham DY. Changing trends in stomach cancer throughout the world. Current gastroenterology reports. 2017;19:36.

14. .Ramezani M, Sahami M, Farshchian N, Almasi A, Sadeghi M. Evaluation of the Prevalence of Clinicopathological and Demographic Factors in Gastric Cancer: A Report from scholar journal of applied medical science 2017;5:4047-50.

15. Raziq AH, Haj SM, Arif SH, Odeesh OY. Gastric Malignancies and the Trend of Gastric Carcinoma in Duhok City-Iraq. Medical Journal of Babylon. 2017;14:162-8.2.

16. Schwartz SI, editor. Principles of Surgery: PreTest Self-assessment and Review. McGraw-Hill, Health Professions Division; 1999.

17. Tredanie J, Boffetta P. Tobacco smoking and gastric cancer: review and meta-analysis. Int J cancer. 1997; 72: 565-73. 56.

18. Abraham M.Y. Nomura, Lynne R. Wilkens et al. The association of cigarette smoking with gastric cancer: the multiethnic cohort study. Cancer causes control. 2012; 23 : 51-58.

19. Praud D, Rota M. et al. Cigarette smoking and gastric cancer in the stomach cancer pooling (STOP) project. Eur. j. cancer. 2016.

20. Edgren G, Hjalgrim H, Rostgaard K, Norda R, Wikman A, Melbye M, Nyrén O. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. American journal of epidemiology. 2010;172:1280-85.

21. Nomura AM, Wilkens LR, Henderson BE, Epplein M, Kolonel LN. The association of cigarette smoking with gastric cancer: the multiethnic cohort study. Cancer Causes & Control. 2012 ;23:51-58

22. Ward BW, Clarke TC, Freeman G, Schiller JS. Early release of selected estimates based on data from the January–September 2014 National Health Interview Survey.

23. Talley NJ, Segal I, Weltman MD, editors. Gastroenterology and hepatology: A clinical handbook. Elsevier Australia; 2008.

 

Statistics
Article View: 255
PDF Download: 114


Journal Management System. Powered by iJournalPro.com