Anticancer Induced Nephrotoxicity: A Review

Hammo, Akram A.; Althanoon, Zeina A.; Ahmad, Abdulla A.

doi:10.33899/iphr.2022.174807

	Anticancer Induced Nephrotoxicity: A Review
Iraqi Journal of Pharmacy
Article 13, Volume 19, Issue 1, 2022, Pages 125-133 PDF (322.62 K)
Document Type: Review Paper
DOI: 10.33899/iphr.2022.174807
Authors
Akram A. Hammo^* ¹; Zeina A. Althanoon²; Abdulla A. Ahmad³
¹The primary health care sector in Al-Baaj, Nineveh Health Directorate, Ministry of Health, Iraq.
²Department of pharmacology and toxicology, College of Pharmacy, University of Mosul, Iraq.
³Department of clinical and laboratory sciences, College of Pharmacy, University of Mosul, Iraq.
Abstract
Introduction: Drug-induced adverse effects are the major challenging issue in the clinical setting of chemotherapy. Kidneys are responsible for the elimination of many chemotherapeutic agents which makes them a common target for adverse effects. Nephrotoxicity is a deleterious adverse effect carrying a great negative impact on body homeostasis and maintenance of cellular functions. Aim: The present review aims to focus on anticancer-induced nephrotoxicity including the causes and mechanisms of toxicity. Methods: Different databases of published materials are recruited mainly from PubMed, Google Scholars, and Iraqi Virtual Science Library. Results: The review shows that the recurrent use of many anticancer drugs can cause different types of kidney damage via different mechanisms. Conclusion: Anticancer-induced nephrotoxicity is a crucial problem which needs more research to clarify the mechanisms of kidney damage and the methods to prevent them. Maintaining appropriate and enough hydration, electrolyte replacement, and avoiding concomitant medications are useful steps in overcoming the nephrotoxicity.
Keywords
anticancer drugs; adverse effect; nephrotoxicity

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