Husein, S., Al-Gharawi, A., Ghareeb, M. (2021). A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy. , 21(3), 274-279. doi: 10.52573/ipmj.1970.175760
Sanaa Nasser Husein; Ali Abbas Al-Gharawi; Mowafaq Mohammad Ghareeb. "A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy". , 21, 3, 2021, 274-279. doi: 10.52573/ipmj.1970.175760
Husein, S., Al-Gharawi, A., Ghareeb, M. (2021). 'A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy', , 21(3), pp. 274-279. doi: 10.52573/ipmj.1970.175760
Husein, S., Al-Gharawi, A., Ghareeb, M. A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy. , 2021; 21(3): 274-279. doi: 10.52573/ipmj.1970.175760

A Comparative Study of Single Dose versus Multiple Dose Prophylactic Ceftriaxone in Laparoscopic Cholecystectomy

Iraqi Postgraduate Medical Journal
Article 4, Volume 21, Issue 3, 2022, Pages 274-279    PDF (178.46 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.1970.175760
Authors
Sanaa Nasser Husein1; Ali Abbas Al-Gharawi2; Mowafaq Mohammad Ghareeb3
1Clinical Pharmacy Specialist, AlKarama Teaching hospital Iraq.
2Baghdad Teaching Hospital, Baghdad, Iraq.
3Department of Pharmaceutics, College of pharmacy, University of Baghdad, Iraq.
Abstract
BACKGROUND:
Although laparoscopic cholecystectomy became the gold standard for the treatment of gallstone disease, there is some risk of surgical site infection that required prophylactic antibiotic. Prophylaxis for low risk patients is still controversial as well as whether single or multiple doses is needed.
AIM OF STUDY:
Compare between single vs. multiple dose of antibiotic prophylaxis in laparoscopic cholecystectomy in terms of post-operative infection and cost.
METHODS:
A prospective study conducted at Baghdad Teaching Hospital, from January 2017 to March 2018. 200 patients admitted for elective laparoscopic cholecystectomy randomly divided in two equal groups: single dose (SD) group was given ceftriaxone (2gm) intravenously at induction of anesthesia, and multiple doses (MD) group was given ceftriaxone (2gm) intravenously at induction of anesthesia followed by ceftriaxone (1gm) intravenously twice a day for two days postoperatively. Surgical site infection and treatment cost in two groups compared and analyzed.
 RESULTS:
 Postoperative infection rate was 1% in both groups; the difference was not significant (p=1).                 The cost was higher in MD group.
CONCLUSION:
Single dose prophylactic antibiotic administered at induction of anesthesia, is equally effective as multiple doses to prevent post-operative infection in low risk patients undergoing laparoscopic cholecystectomy and is cost effective.
 
Keywords
Laparoscopic cholecystectomy; antibiotic prophylaxis; ceftriaxone
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