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Programmed Host Cell Death and Infectious Process of Mycoplasma | ||
| Basrah Journal of Veterinary Research | ||
| Article 5, Volume 21, Issue 3, 2022, Pages 42-57 PDF (1.58 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.23975/bjvetr.2022.175774 | ||
| Authors | ||
| Alaa Abed* 1; Ali Al-Iedani2; Ahmed Neamah3 | ||
| 1Department of Microbiology and Parasitology, College of Veterinary Medicine, University of Basrah, Iraq | ||
| 2Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Al-Qadisiyah, Iraq. | ||
| 3Unit of Zoonotic Diseases, College of Veterinary Medicine, University of Al-Qadisiyah, Iraq. | ||
| Abstract | ||
| A common characteristic of Mycoplasma diseases is their chronicity, Mycoplasma spp. infection have been frequently associated with upper respiratory infections, chronic lung disease , asthma, meningeal encephalitis, mastitis, arthritis, heart problems, sterility, bone problems , oviduct dysfunctions and death in human and different animal species. In former years, changeable expression of membrane antigens has been detected in a number of Mycoplasma spp., resulting in the assumption that immune prevarication may be an important part of the their infection and pathogenesis. It has been determined how the attachment organelle, which mediates the complicated interactions between various adhesins and auxiliary adhesion proteins to mediate the critical first stage of cytoadherence to respiratory tract epithelium. Additionally, it has been demonstrated that inflammatory cytokines cause tissue damage by intracellular localization, direct cytotoxicity, and activation of the inflammatory cascade via Toll-like receptors (TLRs), and inflammosome activation, which causes air passage inflammation. All of these play crucial roles in the infectious process. This paper seeks to provide a thorough assessment of recent developments in our understanding of Mycoplasma pathogenesis with the understanding of its virulence mechanisms. | ||
| Keywords | ||
| Mycoplasmas; infectious process; programmed cell death; apoptosis | ||
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