EFFECT OF GLYCINE ON 5-FLUOROURACIL- INDUCED ORAL MUCOSITIS IN ADULT MALE RATS

Khaphi, Fatin; Al- Derawi, K.

doi:10.23975/bjvetr.2031.175858

	EFFECT OF GLYCINE ON 5-FLUOROURACIL- INDUCED ORAL MUCOSITIS IN ADULT MALE RATS
Basrah Journal of Veterinary Research
Article 8, Volume 20, Issue 1, 2021, Pages 83-91 PDF (4.69 M)
Document Type: Research Paper
DOI: 10.23975/bjvetr.2031.175858
Authors
Fatin Khaphi^* ¹; K. Al- Derawi²
¹Department of Basic science, College of Dentistry, University of Basrah, Basrah, Iraq
²Department of Biology, College of Science, University of Basrah, Basrah, Iraq .
Abstract
The study designed to assess the impact of glycine on 5-FU induced oral mucositis. Twenty five adult male rats were used in this study, and randomly distributed in to three groups: the first group (G1) served as control (5 rats). The other two experimental groups (G2 & G3) (10 rats for each) were received IP injected (60 mg/ kg B. W) of 5-FU one time / week for six weeks. The animals of G3 were received a (2 mg /g B.W.) of 5% glycine once time / day from the first day of experiment till the finish of experiment at 6 weeks. After that, the rats were sacrificed, and the cheek mucosa was removed and processed for light microscope. Histological examination of cheek sections of G2, revealed reduce in thickness of epithelium with secession of keratin, perinuclear vacuolation cells with pyknotic nuclei, intense infiltration of inflammatory cells and the areas of degeneration. Light microscopic analysis of G3 treated with glycine, showed improvement of most histological changes described before as a degree of reepithelization with keratin layer, more proliferation of basal cells, mild inflammatory features with numerous blood capillaries. Glycine shows more fast epithelial differentiation and wound healing.
Keywords
Glycine; 5-FU; Mucositis

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