ANTITUMOR EFFECTS OF LEAVES, STEM, AND ROOT EXTRACTS OF Cichorium intybus IN VITRO AND IN VIVO

Mazyed, Zeyad; Suker, Dhamia; Tawfeeq, Amer

doi:10.23975/bjvetr.1970.175873

	ANTITUMOR EFFECTS OF LEAVES, STEM, AND ROOT EXTRACTS OF Cichorium intybus IN VITRO AND IN VIVO
Basrah Journal of Veterinary Research
Article 18, Volume 20, Issue 1, 2021, Pages 203-225
Document Type: Research Paper
DOI: 10.23975/bjvetr.1970.175873
Authors
Zeyad Mazyed^* ¹; Dhamia Suker¹; Amer Tawfeeq²
¹Department of Biology, College of Science, University of Basrah , Iraq.
²The Iraqi Center for Cancer Research and Medical Genetics, University of AlMustanseria, Iraq.
Abstract
Cichorium intybus or Chicory was used in traditional medicine for curing several diseases such as diarrhea, to improve the prostate and other reproductive organs, to treat lung and tobacco disease, cancer, severe headache, and others. We examined the anti-tumor and antimetastatic effects of C. intybus extracts in vitro and in vivo. Cytotoxicity of C. intybus extracts ( leaf, stem, and root ) was done on the 4T1 cell line; a high significant inhibition value was detected in the 4T1 cell line at three periods of exposure .In vivo study; For 21 days, tumor-bearing female Mus musculus Balb/c mice were given orally one hundred microliters of leaf extract (1000 mg /kg/BW ), whereas the control group received only PBS. Leaf extract induced a significant decrease in tumor size (P < 0.05). There was little indication of liver metastases in leaf extract-treated animals relative to the controls, a markedly less of metastases than expected
Keywords
Antitumor; Cichorium; Line

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