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Synthesis of some sulfonamide derivatives withexpected antibacterial activity | ||
| iraq journal of market research and consumer protection | ||
| Article 1, Volume 1, Issue 1, 2009, Pages 85-93 | ||
| Authors | ||
| K. Y. Saor; A. J. Qasir; S. A. Ali | ||
| Abstract | ||
| Some derivatives of amino acid were synthesized and gave some antibacterial activity. These derivatives were classified according to their attachment to amino acids either to the carbon skeleton, or as esters or amides. It was found from previous researches that the benzene sulfonamides moiety when used in antibacterial agents are essential for their activities. Accordingly, a number of benzene sulfonyl amino acids derivatives were synthesized which differ from traditional sulfanilamides in that they do not contain para-amino group which is essential for their activity. Four derivatives were synthesized and identified using infrared spectroscopy, CHN analysis in addition to thin layer chromatography, melting point and solubility. Three derivatives (benzene sulfonyl of glycine, alanine and methionine) were applied to hospital strains of Escherichia coli and Staphylococcus aureus, all these derivatives were proved to have antibacterial activity and thus are promising target for future work. | ||
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