Histological evaluation of gingival enlargement response to oral folic acid administration in rabbit

Ali, Marwa Hashim; Al Saffar, Maha Talal; Mahmood, Abdulsattar Salim

doi:10.33899/rdenj.2022.130074.1103

	Histological evaluation of gingival enlargement response to oral folic acid administration in rabbit
Al-Rafidain Dental Journal
Article 19, Volume 22, Issue 2, 2022, Pages 409-417 PDF (615.24 K)
Document Type: Research Paper
DOI: 10.33899/rdenj.2022.130074.1103
Authors
Marwa hashim Ali¹; Maha Talal Al saffar^* ²; Abdulsattar Salim mahmood³
¹clinical pharmacist/ department of pharmacy /AI-jumhory teaching hospital/Nineveh health/Mosul, Iraq
²Department of dental basic science
³maxillofacial department/ Mosul, Iraq cie
Abstract
Aims of the study: to clarify the clinical and histological evaluation of oral folic acid effect on reduction of gingival enlargement. Materials and methods: The study was carried out in the collage of dentistry /university of Mosul on twelve white newzeland male rabbit with gingival enlargement weight between (900 g±1.250g). six rabbit considered as control group and the other six rabbit considered as treated group which taking 15 mg orally folic acid once daily for about 14 days then depth of gingival sulcus evaluated clinically by periodontal` probe and euthaniused for histological examination. Result: Clinically: after 14 days of drug administration, there is a high clinical differences between two group (mean +- SD), control group have (3-5mm) of gingival enlargement and experimental group have (1-3 mm) of gingival enlargement. Histological finding show significant differences in the form of gingival sulcus depth and inflammatory cell infiltration and connective tissue in control group and experimental group. Conclusion: the effect of oral administration of folic acid have higher evaluation on reducing the gingival enlargement in rabbit
Keywords
folic acid; gingival enlargement; Histological effect of folic acid on gingiva

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