Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases

Ghanim, Tharee; Omar, Adnan O.

doi:10.33899/rjs.2023.177295

	Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases
Rafidain Journal of Science
Article 14, Volume 32, Issue 1, 2023, Pages 127-137 PDF (768.63 K)
Document Type: Research Paper
DOI: 10.33899/rjs.2023.177295
Authors
tharee Ghanim^* ¹; Adnan O. Omar²
¹Department of Chemistry, College of Science, University of Mosul, Iraq
²Department of Chemistry/ College of Science/ University of Mosul, Mosul-Iraq
Abstract
The present work involves the new chalcones containing Schiff bases, In this study, firstly, reaction of 3-acetylcoumarin with terephthaldehyde to prepared chalcones which contains a free aldehyde group which has been reacted with (4-Aminoantipyrine) to prepare Schiff bases, which was reacted (sodiumazide) as precursor to form (Tetrazole) followed by condensation of these chalcones with some compounds (hydroxylamine, aminophenol, phenylenediamine, hydrazine, semicar- bazide, thiosemicarbazide, urea, thiourea and quanidine) as precursor to form Isoxazole, oxazepane, diazepine, pyrazoles and pyrimidine derivatives in basic medium using classical and ultrasonic technique. The comparison of the classical methods with ultrasonic methods. Was achieved. The compositions of the prepared compounds were confirmed by FT- IR and ¹H NMR spectroscopy.
Keywords
Tetrazole; Isoxazoles; Chalcones; 3- Acetylcoumarin; ultrasonic techniq

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