Study the Effect of Thyroxin and the Aqueous Extract ofBorage (Borago officinalis) on the Activity of Alkaline Phosphatase (ALP) in Neutrophils in Male Albino Mice

A. Sabrei, D.; S. Alkasiy, K.; N. Alawchi, S.

	Study the Effect of Thyroxin and the Aqueous Extract ofBorage (Borago officinalis) on the Activity of Alkaline Phosphatase (ALP) in Neutrophils in Male Albino Mice
iraq journal of market research and consumer protection
Article 1, Volume 1, Issue 2, 2009, Pages 15-28
Authors
D. A. Sabrei; K. S. Alkasiy; S. N. Alawchi
Abstract
This study was conducted to determine the effect of the thyroxin and the aqueous extract of Borage (Borage officinalis) a lone or when they are given together on the activity of leucocyte alkaline phosphatase (ALP) in neutrophils. A total of 35 mature male Swiss albino mice was used in this study. Animals were divided them into two main groups as follows: * The First Group: this group contains four sub groups which were treated for 11 day. Animals weights were measured before the start of the experiments, and these sub groups were: 1. A group treated via thyroxin (subcutaneous) (G1) with concentration 0.2 mg/kg. 2. A group treated with administration with 0.5 ml of the aqueous extract of Borage (G2) with concentration 6 gm/100 ml. 3. A group treated with thyroxin and Borage together (G3). 4. The control group (G4) which was injected with distilled water (subcutaneous) of dose 0.9 ml. * The Second Group: this group contains three sub groups treated for 22 day. All the animals were weighted before experiments, and these sub groups were: 1. A group treated with thyroxin for 11 day then treated with Borage for 11 day too (G5). 2. A group treated with thyroxin for 11 day then the animals were left for 11 day too without any treatment (G6). 3. The control group (G7) which was injected with distilled water (subcutaneous) of dose 0.9 ml. At the end of the treatment period the results showed Intensive enzymatic activity of (ALP) in the neutrophils of the (G1), and the (G6). While a moderate activity was found in the (G3). On other hand a normal activity of the enzyme was observed in the (G2, G4, G5, and G7). We concluded from this study that the treatment with thyroxin induced hyperthyroidism of thyroid gland such the treatment lead to the appearance of an intensive enzymatic activity of (ALP) on the neutrophils, in the other hand the equeous extract of Borage could inhibit such effects of thyroxin on the (ALP) in the neutrophils.

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