Study the Effect of the Aqueous Extract of Borage (Borago officinalis) on the Function and Structure of Thyroid Gland in Male Albino Mice.

A. Sabrei, Dalia; S. Alkasiy, Kawkab; N. Alawchi, Sabah

	Study the Effect of the Aqueous Extract of Borage (Borago officinalis) on the Function and Structure of Thyroid Gland in Male Albino Mice.
iraq journal of market research and consumer protection
Article 1, Volume 1, Issue 2, 2009, Pages 29-41
Authors
Dalia A. Sabrei; Kawkab S. Alkasiy; Sabah N. Alawchi
Abstract
This study was conducted to determine the effect of aqueous extract administration of the aqueous extract of Borage (Borage officinalis) in the function, histopathology, and ultra structure of the thyroid gland, as well as the levels of (T3, T4, TSH) hormones. A total of 20 mature male Swiss albino mice were used and weighted before the experiment started. Animals were divided into two groups as following: * Group One (G1): (Control group) contain 10 Animals were administration daily with 0.5 ml of distilled water for 11 day. * Group Two (G2): Contain 10 Animals administration daily with 0.5 ml of the aqueous extract of Borage with concentration of 6 gm/100 ml for 11 day. At the end of the experiment all animals were weighted and the following results were observed: 1. No significant changes were found in the mean weights of (G2) in comparison with the (G1). 2. A significant increase (P < 0.05) in T4 hormone level was found in (G2) in comparison with the (G1). 3. No significant changes were found in TSH hormone level in (G2) in comparison with the (G1). 4. A significant decrease (P < 0.05) in T3 hormone level was found in the (G2) in comparison with the (G1). 5. Histological examination showed in the (G2) a normal histology appearance of the thyroid in comparison with the (G1) and the colloid reflects a scallope appearance. So we concluded from this study that aqueous extract of Borage had no negative effects in the structure and functio

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