Mass Transfer Coefficient Study for Unloading of Naproxen from Activated Carbon as Drug Delivery

Hameed, Shahad Faiz; Rushdi, Salih A.

doi:10.30772/qjes.v12i4.619

	Mass Transfer Coefficient Study for Unloading of Naproxen from Activated Carbon as Drug Delivery
Al-Qadisiyah Journal for Engineering Sciences
Volume 12, Issue 4, December 2019, Pages 232-239 PDF (1.02 M)
DOI: 10.30772/qjes.v12i4.619
Authors
Shahad faiz Hameed; Salih A. Rushdi
Department of chemical engineering, University of Al-Qadisiyah, Al-Qadisiyah, Iraq
Abstract
Activated carbon is a porous material that has a great character to be used for drug delivery system as carrier.It is agreed that drug carriers maintain the concentration of drugs within the required range for a long period of time and undetermined toxicity resulting from the use of overdoses , the ability to direct the drug to the affected area, immunity, biophysics, and drug efficacy. activated carbon was used in two different particle sizes (0.6µm size with surface area 544.4704 m2/g and 11.042 nm size with surface area 985.6013m2/g ) and Naproxen was used as a drug model. In this research study the effect of the number of parameters, including particle size, weight of drug to carrier weight ratio, on drug loading and temperature, time ,PH solution on mass transfer coefficient in unloading drug. the result of experiments was find that maximum loading efficiency obtain when the particle size of activated carbon was in Nano. size and the ratio of weight drug to AC weight was 1.5. The unloading process was studied by studying the mass transfer coefficient and knowing the effect of the variables on its value ,these variables are time and temperature in addition to the PH value of the solution. The highest value of the mass transfer coefficient was obtained at the beginning of the unloading time ,at temperature 37 co and at solution in PH 6.5 .
Keywords
Activated Carbon; Drug delivery; Loading; Mass Transfer Coefficient; Naproxen; Release

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