Al-Janabi, Z., Al-Qaraghuli, H. (2021). Poly (lactic-co-glycolic Acid) -loaded Fadrozole preparation by nanoprecipitation method. , 20(1), 46-58. doi: 10.29079/qjvms.2021.179342
Zainab Abd Al -khaleq Al-Janabi; Huda Falah Hasan Al-Qaraghuli. "Poly (lactic-co-glycolic Acid) -loaded Fadrozole preparation by nanoprecipitation method". , 20, 1, 2021, 46-58. doi: 10.29079/qjvms.2021.179342
Al-Janabi, Z., Al-Qaraghuli, H. (2021). 'Poly (lactic-co-glycolic Acid) -loaded Fadrozole preparation by nanoprecipitation method', , 20(1), pp. 46-58. doi: 10.29079/qjvms.2021.179342
Al-Janabi, Z., Al-Qaraghuli, H. Poly (lactic-co-glycolic Acid) -loaded Fadrozole preparation by nanoprecipitation method. , 2021; 20(1): 46-58. doi: 10.29079/qjvms.2021.179342

Poly (lactic-co-glycolic Acid) -loaded Fadrozole preparation by nanoprecipitation method

Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 20, Issue 1, May 2021, Pages 46-58    PDF (447.57 K)
Document Type: Research Paper
DOI: 10.29079/qjvms.2021.179342
Authors
Zainab Abd Al -khaleq Al-Janabi* ; Huda Falah Hasan Al-Qaraghuli
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq
Abstract
Nanoparticles were atoms with smaller than one micron. The size of nanoparticles to 1 to 100 nm, poly (lactic-co-glycolic acid) PLGA had important features including biocompatibility, biodegradability, drug delivery systems (DDS), and constant release. The study assessed the nano-precipitation method of PLGA loaded Fadrozole on induced endometrial periglandular fibrosis (EPF) in female mice compared with the reference Fadrozole. Technology was used to create PLGA nanoparticles, the features of PLGA nanoparticles, included an ultraviolet (UV) spectrophotometer test, which resulted in a PLGA-loaded Fadrozole absorbance (4.5452) with a wavelength of 336.32 nm, as well as other tests included (scanning electron microscope, transmission electron microscope, and zeta potential). According to the description of PLGA revealed in this study, the DMSO associated organic phase alone had specified the form, particle size with a small diameter, charged particles in addition to suitable nanoparticle yield percent, encapsulation efficiency, and drug loading with sufficient stabilizer. Finally, we concluded that female mice who were subjected to artificially induced endometrial periglandular fibrosis by daily 17 – estradiol S/C injection and H2O2 treatment with drinking water for 12 weeks were able to cure with the poly (lactic-co-glycolic acid) -Fadozole regimen therapy at various doses.

 
Keywords
Nanoprecipitation; PLGA- loaded Fadrozole
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