- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Prevalence and predictors of severe metabolic acidosis in chronic kidney disease stage 3-5 | ||
| The Medical Journal of Basrah University | ||
| Article 3, Volume 40, Issue 2, June 2022, Pages 111-118 PDF (465.98 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2023.133748.1103 | ||
| Authors | ||
| Hayder Aledani* 1; Jawad Ibrahim Alsharif2 | ||
| 1Medicine, College of Medicine, University of Basrah, Iraq | ||
| 2Arab Board of Health Specialization | ||
| Abstract | ||
| Background and objective Metabolic acidosis is a common metabolic complication of chronic kidney disease with different frequencies across stages of CKD. The objective of the study was to estimate the prevalence and study predictors for development of severe metabolic acidosis in CKD stage 3-5. Methods It was a cross-sectional study of patients aged > 18 years with metabolic acidosis and stage 3-5 CKD for 1 year at two medical centers in Iraq. The prevalence of severe metabolic acidosis and correlation with patients’ characteristics were studied using Fisher exact test for categorical variables and nonparametric independent samples Mann-Whitney U T test. Predictors for severe metabolic acidosis was analyzed using multiple logistic regression. Results Among 117 patients with CKD stage 3-5 and metabolic acidosis, severe metabolic acidosis was reported in 14.5%. It was more frequent in stage 5 CKD compared to stage 4 CKD (64.7% vs 35.3%). Correlation of severe metabolic acidosis was statistically significant with urinary tract obstruction, glomerular diseases, reduced cortical thickness on ultrasonography, anemia, hyperkalemia, hypocalcemia and hyperphosphatemia. By multivariate analysis, female sex, urinary tract obstruction and glomerular diseases were predictors for development of severe metabolic acidosis. Conclusion Severe metabolic acidosis was common in stage 5 CKD. Female sex, urinary tract obstruction and glomerular diseases were predictors for development of severe metabolic acidosis. | ||
| Keywords | ||
| Metabolic acidosis; Chronic kidney disease; Obstructive uropathy | ||
|
Supplementary Files
|
||
|
Statistics Article View: 928 PDF Download: 270 |
||
