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Association of serum uric acid with markers of inflammations And disease severity in ankylosing spondylitis patients | ||
| The Medical Journal of Basrah University | ||
| Article 5, Volume 40, Issue 2, June 2022, Pages 127-133 PDF (421.79 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2023.140380.1128 | ||
| Authors | ||
| Mustafa Omran* 1; faiq isho2 | ||
| 1Alzahraa college of medicine | ||
| 2college of medicine/ baghdad university | ||
| Abstract | ||
| Objective: To clarify the relationships between Serum uric acid with inflammatory laboratory markers and ASDAS-ESR disease activity score in patients with ankylosing spondylitis. Method: A total of 73 ankylosing spondylitis patients with age ≥ 20 years with AS fulfilling ASAS criteria were included cross-sectional study. The laboratory measures included values of uric acid, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) obtained. Disease activity is calculated by Ankylosing Spondylitis Disease Activity Score (ASDAS- ESR). Demographic and laboratory investigations were recorded. Results: The mean age of the studied sample was 35.04±7.99 years with a range of (17-52 years) & the mean Body Mass Index was 27.91 ±5.78 with a range (18-46). The majority of them were married (80.8%), working (94.5%), and non-smokers in (52.1 %) and (94.5%) on biological therapy. Comparing serum uric acid with ESR value revealed no statically significant association (P=0.47). Again, this is observed when comparing serum uric acid with CRP Value (P=0.27). Ultimately, the study failed to demonstrate any affiliation between Serum uric acid with any level of disease activity measured through ASDAS-ESR score (P =0.52). Conclusion: The study was unsuccessful to validate any association between Serum uric acid and the routine inflammatory markers and AS disease activity score (ASDAS-ESR). | ||
| Keywords | ||
| inflammatory markers; uric acid; ankylosing spondilitis | ||
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