Unexpected Presentation for predicted Complication Orbital Lymphoma in a patient with Primary Sjögren Syndrome

Omran, Mustafa E. Omran; Khalaf, Asaad; Saleem, Raghda

doi:10.33762/mjbu.2023.145199.1179

	Unexpected Presentation for predicted Complication Orbital Lymphoma in a patient with Primary Sjögren Syndrome
The Medical Journal of Basrah University
Volume 41, Issue 2, December 2023, Pages 139-145 PDF (479.58 K)
Document Type: Case Report
DOI: 10.33762/mjbu.2023.145199.1179
Authors
Mustafa E. Omran Omran^* ¹; Asaad khalaf^* ²; Raghda Saleem^* ³
¹Lecturer, Department of Medicine, Al-Zahraa College of Medicine, University of Basrah, Basrah, Iraq
²Haematology Subspecialty senior, Head of Haematology Department, Al-Sayyab Teaching Hospital, Basrah, Iraq
³University of Basrah
Abstract
Lymphoid malignancies are the most common primary orbital tumours but they constitute only 2% of extranodal lymphomas. A fifty-year-old lady known case of SS presented with progressive blurred vision and left deep orbital pain for about 5 months duration, with time, she started to develop left eye protrusion with ophthalmoplegia. The histopathological diagnosis was a low-grade follicular (nodular) B cell subtype of non-Hodgkin lymphoma (Grade 2). Immunohistochemically, it displayed CD45 and CD20 positive, stained whole neoplastic variables sizes follicles, CD3 stained rime of non-neoplastic T cells around the follicles. Positron Emission Scan (PET scan) exhibited mild hyper-metabolic multiple right cervical and supraclavicular lymph nodes. Moderately hypermetabolic enlarged abdominal (Left Para-aortic, bilateral common iliac, right external and inguinal lymph nodes). The patient after the 4th cycle of chemotherapy has no palpable cervical lymphadenopathy and restores normal vision in the left eye.
Keywords
Sjogren syndrome; orbital lymphoma; basrah

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