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Clinical and electrophysiological charactrastic of peripheral neuropathy in patients with hematological malignancies receiving chemotherapy Abstract | ||
| The Medical Journal of Basrah University | ||
| Volume 41, Issue 2, December 2023, Pages 165-176 PDF (593.13 K) | ||
| Document Type: Review Paper | ||
| DOI: 10.33762/mjbu.2023.145070.1175 | ||
| Authors | ||
| zainab adil ali* 1; Haitham Jawad Kadhum* 2; Qutaiba Dawood* 3; Lana Kadhim* 4 | ||
| 1Basra health directorate | ||
| 2Department of Physiology, College of Medicine, University of Basrah, Iraq | ||
| 3(Clinical haematology), College of Medicine, University of Basrah, Iraq. | ||
| 4(physiology), Basrah health directorate, Al-Sadar Teaching Hospital | ||
| Abstract | ||
| Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication in cancer patients especially those treated with neurotoxic chemotherapeutic agents. CIPN is usually diagnosed clinically; However, electrophysiologic testing confirm the diagnosis and rule out other potential causes of neuropathic manifestations. Aims: This study aimed to look for electrophysiological changes and clinical features of peripheral neuropathy among patients with haematological malignancies treated with chemotherapy in Basrah governorate, southern Iraq Methods: A case-control study conducted in Basrah city, southern Iraq. The study involved 109 patients with confirmed diagnosis of multiple myeloma, leukaemia, and lymphoma. Their clinical, and electrophysiological characteristics using nerve conduction studies and needle electromyography have been registered. Results: The proportion of CIPN among patients with hematological malignancies is 38.53%. All of the cases were axonal polyneuropathy, with 54.76% were sensory followed by 45.24% mixed sensory motor neuropathy. Clinically, 55.96% of the cases reported lower limb paresthesia and numbness and 11.01% reported limb weakness. Sensory nerve conduction studies showed reduction in the amplitude of sural and ulnar nerves. Moreover, motor nerve conduction studies also showed reduction in the amplitude of peroneal and ulnar nerves Conclusions: Chemotherapy regimen induced peripheral neuropathy; the pattern was distal, symmetrical, length-dependent, axonal polyneuropathy of pure sensory mainly followed by mixed sensory-motor type. We recommend screening schedule for early detection of PN, further study to compare pre and post treatment changes with larger sample size and longer follow up duration. | ||
| Keywords | ||
| CIPN; EMG; NCS; leukemia; neurophysiology | ||
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