Ali, A., Khalaf, M., Ahmad, A. (2024). A Comprehensive View on Drugs-Induced Cardiotoxicity and Its Prevention. , 21(1), 20-35. doi: 10.33899/iphr.2024.145016.1070
Abdulnaser Ahmad Ali; Musab Mohammed Khalaf; Abdulla A. Ahmad. "A Comprehensive View on Drugs-Induced Cardiotoxicity and Its Prevention". , 21, 1, 2024, 20-35. doi: 10.33899/iphr.2024.145016.1070
Ali, A., Khalaf, M., Ahmad, A. (2024). 'A Comprehensive View on Drugs-Induced Cardiotoxicity and Its Prevention', , 21(1), pp. 20-35. doi: 10.33899/iphr.2024.145016.1070
Ali, A., Khalaf, M., Ahmad, A. A Comprehensive View on Drugs-Induced Cardiotoxicity and Its Prevention. , 2024; 21(1): 20-35. doi: 10.33899/iphr.2024.145016.1070

A Comprehensive View on Drugs-Induced Cardiotoxicity and Its Prevention

Iraqi Journal of Pharmacy
Article 4, Volume 21, Issue 1, March 2024, Pages 20-35    PDF (850.57 K)
Document Type: Review Paper
DOI: 10.33899/iphr.2024.145016.1070
Authors
Abdulnaser Ahmad Ali* 1; Musab Mohammed Khalaf2; Abdulla A. Ahmad3
1College of Pharmacy, Mosul University, Mosul, Iraq
2Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq
3Department of Clinical Lab Sciences, College of Pharmacy, University of Mosul, Mosul, Iraq.
Abstract
Background: The prevention of drug-induced cardiotoxicity is a complicated challenge facing healthcare providers during the last few decades. This challenge is raised from the unclear definition of the term “cardiotoxicity”, the overlapping of the symptoms of heart dysfunction due to the underlying diseases and the used drugs or using a combination of drugs which makes it difficult to distinguish between the side effects of each drug. Objective: This review discusses the most causative agents of cardiotoxicity, and their mechanisms to induce cardiac muscle damage, and finally focuses on the most applicable methods to deal with these dangerous heart problems. Methods: The search method involved electronic databases, including PubMed, Web of Science, Springer, Google Scholar, and others to resume relevant trials of heart disease published in the period between 2010-2023. Conclusion: Cardiotoxicity is a common substantial adverse effect of many drugs including anticancer drugs and others. The prevention methods may include medications, such as (Enalapril or carvedilol), supplementation with antioxidants, or cardioprotective natural products.

Highlights
  • Cardiotoxicity is a serious adverse effect affecting the heart resulting from many drugs, especially anticancer drugs.
  • The mechanism of cardiotoxicity involves reactive oxygen species formation, depletion of antioxidants, and mitochondrial damage.
  • Prevention of drug-induced cardiotoxicity requires the use of drugs (enalapril, carvedilol), natural products, and antioxidants.
Keywords
Cardiotoxicity; Anticancer drugs; Cardioprotection; Antioxidants
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