The Effect of FSH and Letrozole Treatment on The Lipid Profile in Women Being Treated for Fertility

Humaidan, Rana Kadhim; Al-Azzawi, Buthainah

doi:10.57238/tpb.2023.146374.1005

	The Effect of FSH and Letrozole Treatment on The Lipid Profile in Women Being Treated for Fertility
Trends in Pharmaceutical Biotechnology
Volume 1, Issue 2, December 2023, Pages 1-10 PDF (2.54 M)
Document Type: Original article
DOI: 10.57238/tpb.2023.146374.1005
Authors
Rana Kadhim Humaidan^* ; Buthainah Al-Azzawi^*
Department of Biochemistry, College of Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.
Abstract
Background: Letrozole, an aromatase inhibitor, affects the ovaries, breasts, adipose tissue, and bone by preventing androgen-to-estrogen conversion. This drastically reduces estrogen’s effects. Estrogens regulate fat metabolism by influencing lipid and lipoprotein metabolism. FSH stimulation, which induces ovulation in non-pregnant women, may help pituitary dysfunction. Regulated ovarian hyperstimulation stimulation increases follicles during in vitro fertilization. Background: Letrozole, an aromatase inhibitor, affects the ovaries, breasts, adipose tissue, and bone by preventing androgen-to-estrogen conversion. This drastically reduces estrogen’s effects. Estrogens regulate fat metabolism by influencing lipid and lipoprotein metabolism. FSH stimulation, which induces ovulation in non-pregnant women, may help pituitary dysfunction. Regulated ovarian hyperstimulation stimulation increases follicles during in vitro fertilization. The aim: To assess the difference in the level of fat (total cholesterol, triglycerides levels, HDL, LDL, and VLDL) of infertility treatment among the three study groups, the group that received HSF, the group that took Letrozole, and the control group. Methods: From October 2022 to May 2023, research was carried out. It featured 120 women who were split into three groups: those who took Letrozole consistently for a month or more in a row, those who received FSH injections continuously for a month or more in a row, and the control group who did not take any medications to promote ovulation. Results: The results show increased levels of total cholesterol, triglycerides, LDL cholesterol, and VLDL cholesterol in LET compared with other groups FSH and control. Our study showed a significant difference (p-value < 0.0001) in the concentrations of TG compared to all studied groups, when the results show decreased levels of HDL cholesterol in LET compared with other groups FSH and control, a significant difference is showed (p-value <0.0001) in the concentrations of HDL cholesterol compared to all studied groups. Conclusion: Letrozole and FSH has modulated lipid profile via increasing triglyceride, cholesterol, HDL, LDL, and VLDL, with greater impact achieved by FSH and letrozole.
Keywords
Ovulation; FSH; Letrzole; Cholesterol; Triglycerides; HDL; LDL; VLDL

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