Al Atraqchi, A. (2024). The Impact of Gamma Knife Radiosurgery on Survival Period of Patients with Brain Gliomas. , 23(1), 59-66. doi: 10.52573/ipmj.2024.182885
Ahmed A Salam Al Atraqchi. "The Impact of Gamma Knife Radiosurgery on Survival Period of Patients with Brain Gliomas". , 23, 1, 2024, 59-66. doi: 10.52573/ipmj.2024.182885
Al Atraqchi, A. (2024). 'The Impact of Gamma Knife Radiosurgery on Survival Period of Patients with Brain Gliomas', , 23(1), pp. 59-66. doi: 10.52573/ipmj.2024.182885
Al Atraqchi, A. The Impact of Gamma Knife Radiosurgery on Survival Period of Patients with Brain Gliomas. , 2024; 23(1): 59-66. doi: 10.52573/ipmj.2024.182885

The Impact of Gamma Knife Radiosurgery on Survival Period of Patients with Brain Gliomas

Iraqi Postgraduate Medical Journal
Article 10, Volume 23, Issue 1, January 2024, Pages 59-66    PDF (247.86 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2024.182885
Author
Ahmed A Salam Al Atraqchi*
Consultant Neurosurgeon, Saad Al- Witry Neuroscience Hospital/ Baghdad, Iraq
Abstract
BACKGROUND:
Brain Glioma is one of the most common brain tumors that starts in the Glial cells of the brain which are the supportive tissue of the brain. Gliomas compromise about thirty percent of all brain tumors.
OBJECTIVE:
Evaluate the outcome of gamma knife radiosurgery as an effective treatment modality in the management of brain glioma.
PATIENTS AND METHODS:
A clinical retrospective study performed and conducted at Neurosciences hospital between January 2017 and November 2018. The cases conducted were 40 cases, 33 patients were undergone craniotomy prior     to radiosurgery and the remaining 7 patients had radiosurgery with gamma knife as the first modality               of treatment.
RESULTS:
Gamma Knife Radiosurgery has showed a good effect on tumor growth control and improving clinical outcome. In high grade glioma Gamma Knife Radiosurgery showed a good noticeable efficacy on prolongation of survival period and tumor control.
CONCLUSION:
Gamma Knife Radiosurgery gained an important role in the treatment of glioma in the last two decades  in selected cases.
 
Keywords
Gamma Knife; Glioma; Radiosurgery
References
  1. Mamelak AN, Jacoby DB "Targeted Delivery of Antitumoral Therapy to Glioma and Other Malignancies with Synthetic Chlorotoxin (TM-601)". Expert Opin Drug Deliv. 2007: 83-102.
  2. Goodenberger ML, Jenkins RB. "Genetics of adult glioma". Cancer Genet. 2012;205:613–21. doi:10.1016/j.cancergen.2012.10.009. PMID 23238284.
  3. "Gliomas". Johns Hopkins Medicine Health Library.
  4. Louis, David N.;…..etal . "The 2016 World Health Organization Classification of Tumors of the Central Nervous System.
  5. Louis, David N.; Ohgaki, Hiroko; Wiestler, O. D.; Cavenee, W. K., eds. (2016). WHO classification of tumours of the central nervous system. World Health Organization (Revised 4th ed.). Lyon: International Agency for Research on Cancer.
  6. Boele FW, Douw L, Reijneveld JC, et al. Health-related quality of life in stable, longterm survivors of low-grade glioma. J Clin Oncol. 2015;33:1023-29.
  7. Reuss, D; von Deimling, A. Hereditary tumor syndromes and gliomas. Recent Results in Cancer Research. Fortschritte der Krebsforschung. Progres dans les Recherches Sur le Cancer. Recent Results in Cancer Research. 2009;171: 83–102.
  8. Plathow C, Schulz-Ertner D, Thilman C, et al. Fractionated stereotactic radiotherapyin low-grade astrocytomas: long-term outcome and prognostic factors. Int J Radiat Oncol Biol Phys. Nov 15 2003;57:996-1003.
  9. El-Shehaby AM, Reda WA, Abdel Karim KM, Emad Eldin RM, Esene IN. GammaKnife radiosurgery for low-grade tectal gliomas. Acta Neurochir. 2015;157:247-56.
  10. Minniti G, Armosini V, Salvati M, Lanzetta G, Caporello P, Mei M, et al. Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma. J Neurooncol. 2011;103:683–91.
  11. Kong DS, Lee JI, Park K, Kim JH, Lim DH, Nam DH. Efficacy of stereotactic radiosurgery as a salvage treatment for recurrent malignant gliomas. Cancer. 2008;112:2046–51.
  12. Larson DA, Prados M, Lamborn KR, Smith V, Sneed PK, Chang S, et al. Phase II study of high central dose gamma knife radiosurgery and marimastat in patients with recurrent malignant glioma. Int J Radiat Oncol Biol Phys. 2002;54:1397–1404.
  13. Combs SE, Widner V, Thilmann C, Hof H, Debus J, Schulz-Ertner D. Stereotactic radiosurgery (SRS): Treatment option for recurrent glioblastoma multiforme (GBM) Cancer. 2005;104:2168–73.
  14. Cuneo KC, Vredenburgh JJ, Sampson JH, Reardon DA, Desjardins A, Peters KB, et al. Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2012;82:2018–24.
  15. Niyazi M, Siefert A, Schwarz SB, Ganswindt U, Kreth FW, Tonn JC, et al. Therapeutic options for recurrent malignant glioma. Radiother Oncol. 2011:1-14.
  16. Yu JB, Schulder M, Knisely J. Radiosurgical dose selection for brain metastasis. Prog Neurol Surg. 2012;25:139-47.
  17. Frischer JM, Fraller A, Mallouhi A, et al. Evaluation of Dose-Staged Gamma Knife Radiosurgical Treatment Method for High-Risk Brain Metastases. World Neurosurgery. 10// 2016;94:352-59.
 

Statistics
Article View: 288
PDF Download: 124


Journal Management System. Powered by iJournalPro.com