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Effects of Dpyridamole on Histopathology of Salivary Glands in Rabbits | ||
| Al-Rafidain Dental Journal | ||
| Article 17, Volume 24, Issue 1, March 2024, Pages 165-173 PDF (1.35 M) | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/rdenj.2024.145627.1239 | ||
| Authors | ||
| Abdulsattar Salim Mahmood1; Faehaa Azher Al-Mashhadane2; Asmaa Y. Thanoon3 | ||
| 1Department of Oral and Maxillofacial Surgery, University of Mosul, Iraq | ||
| 2Department of Dental Basic Sciences, University of Mosul, Iraq. | ||
| 3Department of Dental Basic Sciences, University of Mosul, Iraq | ||
| Abstract | ||
| Aims: Dipyridamole is a well-known coronary vasodilator. It is an adenosine reuptake inhibitor leading to increased blood levels of adenosine. So, this study aims to investigate the effects of systemic administration of dipyridamole on the salivary gland tissues in the rabbit model. Materials and methods: Ten male rabbits with a body weight of 1.50 ± 0.25kg were involved. The control group (5 animals) received no treatment, while the treatment group (5 animals) was treated with dipyridamole by gavage tube at an oral dose of 8 mg/kg once daily for 30 days. Then all animals were sacrificed and tissue sample sections from the salivary glands were subjected to a hematoxylin-eosin stain and evaluated for histopathological examination. Results: Histopathological slides of parotid and submandibular glands in the treatment group showed abnormal changes in the structure of acinar cells and the cells lining the striated ducts. Sections of parotid displayed necrosis of the cells of serous acini and the cells lining the striated ducts, with the presence of hemorrhage around these ducts. Conclusions: Increased levels of adenosine in the body microenvironment induced by systemic administration of the dipyridamole can cause salivary gland tissue disturbance. | ||
| Keywords | ||
| Keywords: dipyridamole; tongue; salivary glands; rabbit | ||
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