Alsadoon, H. (2024). Improving liver metabolite performance and immune system reaction after treatment with camel milk in food-based poisoned rats. , 23(1), 10-18.
Hanoaf Shugaa Ali Alsadoon. "Improving liver metabolite performance and immune system reaction after treatment with camel milk in food-based poisoned rats". , 23, 1, 2024, 10-18.
Alsadoon, H. (2024). 'Improving liver metabolite performance and immune system reaction after treatment with camel milk in food-based poisoned rats', , 23(1), pp. 10-18.
Alsadoon, H. Improving liver metabolite performance and immune system reaction after treatment with camel milk in food-based poisoned rats. , 2024; 23(1): 10-18.

Improving liver metabolite performance and immune system reaction after treatment with camel milk in food-based poisoned rats

Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 23, Issue 1, May 2024, Pages 10-18    PDF (689.23 K)
Document Type: Research Paper
Author
Hanoaf Shugaa Ali Alsadoon*
Intermediate school Youssef Al siddiq, Al-Kut City, Iraq.
Abstract
Mycotoxins represent a continuous major problem that face food industry around the world due to their health impacts on humans and animals. Research studies that target citrinin mycotoxin are at a limit range. The current study was carried out to explore the ameliorative effects of camel milk (CMk) on the rats exposed to citrinin (CTN) at the levels of liver function, cytokine response, hepatic tissue lipid profile, hepatic tissue antioxidant activity, and gene expression of some repair related genes in tissue. According to these, an experiment that lasted for 20 days included the recruitment of 24 male rats into four groups (control group: received no treatment, CMk group: received 1.25 ml/kg B Wt of CMk orally, CTN group: received CTN at 10 mg/kg diet, and CTN+CMk: received both CTN and CMk at the same doses). After the end of the experiment, blood samples were collected from all animals before scarification. Blood samples were utilized for AST, ALT, ALP, LDH, GGT, and Ck liver function enzymes and in IL-6 and IL-1b responses. Liver tissues were employed for the detection of GSH and SOD activities and in APE1 and OGG1 gene expression. The findings of the liver function demonstrated significant (p<0.05) improvements in the enzyme and cytokines levels in the CTN+CMk group comparing with both control and CTN groups. Moreover, antioxidant and gene activities recorded significant (p<0.05) alterations in the CTN+CMk group. The present study results display important data about the improving effects of camel milk on the citrinin-intoxicated rats.
Keywords
Aspergillus; citrinin; fungi; immune system; liver enzymes; mycotoxin
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