Influence of different aspirin doses on kidney tissue and blood parameters in rats

ALBsateen, Sondos Hussein Ali; Alethari, Ishtar Adnan Mohammed

doi:10.29079/qjvms.2023.183395

	Influence of different aspirin doses on kidney tissue and blood parameters in rats
Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 22, Issue 2, September 2023, Pages 45-55 PDF (1.22 M)
Document Type: Research Paper
DOI: 10.29079/qjvms.2023.183395
Authors
Sondos Hussein Ali ALBsateen¹; Ishtar Adnan Mohammed Alethari²
¹Department of Physiology and pharmacology, College of Veterinary Medicine, University of Al-Muthana, Iraq
²Head of the Department of Physiology and pharmacology, College of Veterinary Medicine, University of Al-Qadisiyah, Iraq
Abstract
Acetylsalicylic acid (ASA), usually referred to aspirin, is a nonsteroidal anti-inflammatory medication (NSAID) used as an anticoagulant to treat pain, fever, inflammation and to treat a variety of inflammatory disorders, including Kawasaki disease, pericarditis, and rheumatic fever. In addition to being an antithrombotic, aspirin also lowers the risk of heart attacks. We investigated the effect of aspirin on RBC, Hb, and PCV and renal functional enzyme (urea, Creatinine and uric acid) using different doses of aspirin in healthy adult rats and at the same time clarify its effect on renal tissue. This study included 50 Wistar adult rats were divided into five groups as following; control, G1, G2, G3, and G4, rats in control group drenched distilled water daily, while the rest groups drenched daily with aspirin 30, 70, 100, and150 mg/kg using gastric lavage sequentially. Blood samples were collected from heart for blood parameter and kidney functional enzymes assessment. Kidney tissues were collected for histological process. The results showed decreased in the serum level of RBC, Hb, and PCV; likewise, there was increase in urea and creatinine level. While, there was a decrease in uric acid serum level. In tissue samples, results showed mild atrophy to extensive necrosis in renal tissue samples with cystic dilation in convoluted tubules of the kidney. In summary, current research showed that the use of different aspirin doses over a period of time has a negative impact on blood parameters and renal functional enzymes. Furthermore, the use of aspirin in this way had an adverse effect on renal tissue.
Keywords
Aspirin; kidney; necrosis; RBC; and creatinine

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