Muhammed Ali, H., Ahmed, B. (2024). Immunohistochemical Expression of Annexin A5 in Invasive Ductal Carcinoma and Fibroadenoma of the Breast. , 23(2), 157-162. doi: 10.52573/ipmj.2024.183509
Husam Muhanned Muhammed Ali; Basim Shehab Ahmed. "Immunohistochemical Expression of Annexin A5 in Invasive Ductal Carcinoma and Fibroadenoma of the Breast". , 23, 2, 2024, 157-162. doi: 10.52573/ipmj.2024.183509
Muhammed Ali, H., Ahmed, B. (2024). 'Immunohistochemical Expression of Annexin A5 in Invasive Ductal Carcinoma and Fibroadenoma of the Breast', , 23(2), pp. 157-162. doi: 10.52573/ipmj.2024.183509
Muhammed Ali, H., Ahmed, B. Immunohistochemical Expression of Annexin A5 in Invasive Ductal Carcinoma and Fibroadenoma of the Breast. , 2024; 23(2): 157-162. doi: 10.52573/ipmj.2024.183509

Immunohistochemical Expression of Annexin A5 in Invasive Ductal Carcinoma and Fibroadenoma of the Breast

Iraqi Postgraduate Medical Journal
Article 6, Volume 23, Issue 2, April 2024, Pages 157-162    PDF (448.54 K)
Document Type: Research Paper
DOI: 10.52573/ipmj.2024.183509
Authors
Husam Muhanned Muhammed Ali* 1; Basim Shehab Ahmed2
1Al-Nu’man Teaching Hospital, Baghdad, Iraq.
2Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Abstract
BACKGROUND:
Breast cancer is the most common cancer. The commonest type of breast cancer is invasive ductal carcinoma. Fibroadenoma a common benign lesion occur in about one in four women. Annexin-A5 is a tumor marker which is a member of the calcium phospholipid binding protein family that could promote tumorigenesis and progression in certain types of cancers.
OBJECTIVE:
Study the expression of AnnexinA5 in breast cancer and fibroadenoma and correlate the result of study with the clinico-pathological parameters.
PATIENTS AND METHODS:
Comparative case - control study included two groups, group A 30 patients with breast cancer and group B 30 patients with fibroadenoma. Each block of all groups of cases was sliced into two slides (one for Hematoxylin and eosin and the other for immunohistochemistry study). 
RESULTS:
AnnexinA5 expression in fibroadenoma was found in 100% of cases which is greater than its expression in invasive ductal carcinoma (70% of cases). There was no significant correlation between A5 expression & age of patients, histologic grade, perineural invasion, vascular invasion and necrosis in invasive ductal carcinoma.
CONCLUSION:
According to the results of present study it was concluded that there is a significant expression of AnnexinA5 in fibroadenoma correlated with age, and non-significant expression of AnnexinA5 in invasive ductal carcinoma in correlation with age, grade, necrosis, vascular and perineural invasion.
 
Keywords
AnnexinA5; breast cancer; Invasive ductal carcinoma; fibroadenoma
Supplementary Files
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