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Level of microRNA Expression and Blood Picture of Car Repairing Workers Compared with a Sample of Patients with Chronic myeloid leukemia in Anbar Province | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 18, Issue 1, June 2024, Pages 60-66 PDF (493.72 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2023.144059.1149 | ||
| Authors | ||
| Sabaa Hussam Araim* ; Nagam Khudhair | ||
| Department of Biology, College of Education for Women, University Of Anbar, Anbar, Iraq. | ||
| Abstract | ||
| Benzene is a chemical that causes many health problems; a close relationship has been found between benzene and leukemia; MicroRNAs can also be used as biomarkers that provide values for cancer diagnosis and prognosis. This study aimed to investigate and evaluate the gene expression levels of miR-124, MiR-22, and MiR-155 genes and their concentration levels in the blood serum of male car repairing workers in the city of Ramadi, Anbar Province and compared with patients with chronic myeloid leukemia and healthy People as a control group. In addition, it showed changes in the physiological properties of blood car repairing workers and a group of CML patients and compared them to healthy subjects.Results: The results of gene expression between MiR-124, MiR-22, and MiR-155 genes showed statistically significant differences at the probability level (P ≤ 0.05) with an increase in the level of gene expression of the MiR-124 gene by (7.6) in the patient group, and increase the level of genes expression of miR-22 gene in the category of mechanics was (3.03), Similar to increased levels of gene expression of the MiR-155 gene by (3.63) in the group of patients. Conclusion: The higher expression level of the study genes coincided with the rise in blood tests in patients and car repairing workers. Therefore, the results obtained from the study showed that gene expression levels are closely related to the biochemical properties of CML patients and car repairing workers. | ||
| Keywords | ||
| MicroRNA; Chronic myeloid leukaemia; Blood picture; Car Repairing Workers | ||
| References | ||
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