- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
The effect of Beta-aminobutyric acid (BABA) on Staphylococcus aureus bacteria and some interleukins | ||
| Journal of University of Anbar for Pure Science | ||
| Volume 18, Issue 1, June 2024, Pages 140-146 PDF (730.51 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2024.146193.1179 | ||
| Authors | ||
| Aisha Ibrahim Hamad* ; Mohammed Abbas Jasim | ||
| Department of Biology, College of Education for Women, University of Anbar,Ramadi, Iraq | ||
| Abstract | ||
| β-amino butyric acid (BABA) is one of the rare free compounds found in nature. It is recognized for its ability to enhance plant immunity against a wide range of diseases, including viruses, bacteria, fungus, and worms. This research aimed the effects of BABA on Staphylococcus aureus isolated from Sprague-Dawley male rats' feces and on IL-4, IL-10, and IL-27. The study included 25 Sprague-Dawley male rats, divided into five groups, each group contain 5 rats, The first group for control, while the second, third ,fourth, and fifth groups for rats dosed orally with different concentration of BABA as (0.250 ,0.315,0.358,0.360) mg/kg respectively, all rats dosed twice in week and for four weeks. The result show one isolate from the control group was found at each stages (T1, T2, T3, T6, T7) and none at (T5 and T8). In the second group, one isolate was in each stage T2, T3, T7, and none in T1, T5, and T8. In the third group, one isolate was at each stage (T2, T3, T4, and T7) and none in other stages. Groups four and five showed no Staphylococcus aureus growth. The study show significant increase of IL-27 in fifth group (98.60 ±1.57) in comparison with control (70.60 ±0.75). Furthermore significant increase IL-10 in fourth and fifth groups (1082.83 ±23.33, 1104.36 ±43.44) respectively in comparison with control (504.06 ±7.12). While IL-4 decrease in the fourth and fifth groups (8.04 ±0.78 , 14.07 ±0.16) respectively in comparison with control (34.89 ±1.51). | ||
| Keywords | ||
| Beta-aminobutyric acid (BABA); IL-4; IL-10; IL-27; Staphylococcus aureus | ||
| References | ||
|
[1] I. Pena, J. J. Picazo, C. Rodríguez-Avial, and I. Rodríguez-Avial, "Carbapenemase-producing Enterobacteriaceae in a tertiary hospital in Madrid, Spain: high percentage of colistin resistance among VIM-1-producing Klebsiella pneumoniae ST11 isolates," International journal of antimicrobial agents, vol. 43, no. 5, pp.460464,2014.https://doi.org/10.1016/j.ijantimicag.2014.01.021
[2] J. Chen et al., "Interaction between microbes and host intestinal health: modulation by dietary nutrients and gut-brain-endocrine-immune axis," Current Protein and Peptide Science, vol. 16, no. 7, pp. 592-603, 2015.
[3] E. Thursby and N. Juge, "Introduction to the human gut microbiota," Biochemical journal, vol. 474, no. 11, pp. 1823-1836, 2017. https://doi.org/10.1042/BCJ20160510
[4] E. A. Al-Dulaimy and M. A. Jasim, "Effect of non-protein amino acids β-amino butyric acid (BABA) on the intestinal G-bacterial community,"2022.https://doi.org/10.21203/rs.3.rs-1955225/v1
[5] L. Zimmerli, B. H. Hou, C. H. Tsai, G. Jakab, B. Mauch‐Mani, and S. Somerville, "The xenobiotic β‐aminobutyric acid enhances Arabidopsis thermotolerance," The Plant Journal, vol. 53, no. 1, pp. 144-156, 2008. https://doi.org/10.1111/j.1365313X.2007.03343.x
[6] A. R. Slaughter, M. M. Hamiduzzaman, K. Gindro, J.-M. Neuhaus, and B. Mauch-Mani, "Beta-aminobutyric acid-induced resistance in grapevine against downy mildew: involvement of pterostilbene," The Downy Mildews-Genetics, Molecular Biology and Control, pp. 185-195, 2008. https://doi.org/10.1007/978-1-4020-8973-2_14
[7] Z. M. S. M. A. Jasim, "The effect of Beta-amino Butyric Acid in Levels of Interleukin4 & Interleukin 10, Complement Proteins C3 & C4 and Immunoglobin IgM in Males Rats Sprague Dawley Infected with Pseudomonas aeruginosa," Prof. RK Sharma, vol. 14, no. 2, p. 269, 2020.
[8] E. A. M. Al-Dulaimy and M. A. Jasim, "Effect Of Non-Protein Amino Acid (BABA) On Gastrointestinal Tissues Of Male Rats And Some Negative Enterobacteria," Journal of Pharmaceutical Negative Results, pp. 219-225, 2022.https://doi.org/0.47750/pnr.2022.13.S02.31
[9] V. L. Ferreira, H. H. Borba, A. d. F. Bonetti, L. Leonart, and R. Pontarolo, "Cytokines and interferons: types and functions," Autoantibodies and cytokines, vol. 13, 2018.
[10] D. A. Vignali and V. K. Kuchroo, "IL-12 family cytokines: immunological playmakers," Nature immunology, vol. 13, no. 8, pp. 722-728, 2012. https://doi.org/10.1038/ni.2366
[11] T. Mathur, S. Singhal, S. Khan, D. Upadhyay, T. Fatma, and A. Rattan, "Detection of biofilm formation among the clinical isolates of staphylococci: an evaluation of three different screening methods," Indian journal of medical microbiology, vol. 24, no. 1, pp. 25-29, 2006. https://doi.org/10.1016/S0255-0857(21)02466-X
[12] M. Perret-Gentil, "Rat Biomethodology. University Veterinarian & Director," Laboratory Animal Resources Center. The University of Texas at San Antonio.(210), pp. 458-6173, 2010.
[13] S. SAS, "Statistical Analysis System, User’s Guide. Statistical. Version 9," SAS. Inst. Inc. Cary. NC USA, 2012.
[14] F. Bellameche, M. A. Jasim, B. Mauch-Mani, and F. Mascher, "Histopathological aspects of resistance in wheat to Puccinia triticina, induced by Pseudomonas protegens CHA0 and β-aminobutyric acid," Phytopathologia Mediterranea, vol. 60, no. 3, pp. 441-453, 2021.
[15] M. A. Jasim and A. Zgair, "Hematological regulation using β-aminobutyric acid in staphylococcus aureus infected rats," Journal of Biotechnology Research Center, vol. 16, no. 2, pp. 22-30, 2022. https://orcid.org/0000-0002-3247-5532
[16] H.-l. Yu, J.-Y. Kim, S.-H. Lim, and H.-W. Kang, "The defense response of pepper (Capsicum annuum L.) induced by exopolysaccharide from Schizophyllum commune," Physiological and Molecular Plant Pathology, vol. 118, p. 101810, 2022. https://doi.org/10.1016/j.pmpp.2022.101810
[17] H. M. Khlaif, O. N. Rajeh, B. I. Wreikat, and I. M. Abu-Obeid, "Induce resistance against bacterial speck disease of tomato Pseudomonas syringae pv. tomato by the chemical inducer ß-aminobutyric acid," Bulgarian Journal of Agricultural Science, vol. 26, no. 2, 2020.
[18] M. Ansari, S. Taghavi, H. Hamzehzarghani, and A. Afsharifar, "Induction of resistance in tomato by β-aminobutyric acid against Clavibacter michiganensis subsp. michiganensis Ta18 strain isolated from Iran," Iranian Journal of Plant Pathology, vol. 55, no. 3, 2020.
[19] X. Ma et al., "Activation of GABAA receptors in colon epithelium exacerbates acute colitis," Frontiers in immunology, vol. 9, p. 987, 2018. https://doi.org/10.3389/fimmu.2018.00987
[20] X. Wu, Y. Zheng, J. Ma, J. Yin, and S. Chen, "The effects of dietary glycine on the acetic acid-induced mouse model of colitis," Mediators of inflammation, vol. 2020, 2020. https://doi.org/10.1155/2020/5867627
[21] S. Kong, Y. H. Zhang, and W. Zhang, "Regulation of intestinal epithelial cells properties and functions by amino acids," BioMed research international, vol. 2018, 2018. https://doi.org/10.1155/2018/2819154
[22] I. Yusufu et al., "A tryptophan-deficient diet induces gut microbiota dysbiosis and increases systemic inflammation in aged mice," International journal of molecular sciences, vol. 22, no. 9, p. 5005, 2021. https://doi.org/10.3390/ijms22095005 | ||
|
Statistics Article View: 784 PDF Download: 194 |
||