R. Abdul Kareem, R., H. Sayer, S. (2024). PHYTOCHEMICAL AND PROTECTIVE EFFECT OF SAUSSUREA COSTUS EXTRACT ON SOME PHYSIOLOGICAL AND HISTOLOGICAL PARAMETERS IN ALBINO RATS INDUCED WITH CHLORPROMAZINE IN THE TESTIS. , 22(1), 82-94. doi: 10.32649/ajas.2024.142234.1066
R. R. Abdul Kareem; Sh. H. Sayer. "PHYTOCHEMICAL AND PROTECTIVE EFFECT OF SAUSSUREA COSTUS EXTRACT ON SOME PHYSIOLOGICAL AND HISTOLOGICAL PARAMETERS IN ALBINO RATS INDUCED WITH CHLORPROMAZINE IN THE TESTIS". , 22, 1, 2024, 82-94. doi: 10.32649/ajas.2024.142234.1066
R. Abdul Kareem, R., H. Sayer, S. (2024). 'PHYTOCHEMICAL AND PROTECTIVE EFFECT OF SAUSSUREA COSTUS EXTRACT ON SOME PHYSIOLOGICAL AND HISTOLOGICAL PARAMETERS IN ALBINO RATS INDUCED WITH CHLORPROMAZINE IN THE TESTIS', , 22(1), pp. 82-94. doi: 10.32649/ajas.2024.142234.1066
R. Abdul Kareem, R., H. Sayer, S. PHYTOCHEMICAL AND PROTECTIVE EFFECT OF SAUSSUREA COSTUS EXTRACT ON SOME PHYSIOLOGICAL AND HISTOLOGICAL PARAMETERS IN ALBINO RATS INDUCED WITH CHLORPROMAZINE IN THE TESTIS. , 2024; 22(1): 82-94. doi: 10.32649/ajas.2024.142234.1066

PHYTOCHEMICAL AND PROTECTIVE EFFECT OF SAUSSUREA COSTUS EXTRACT ON SOME PHYSIOLOGICAL AND HISTOLOGICAL PARAMETERS IN ALBINO RATS INDUCED WITH CHLORPROMAZINE IN THE TESTIS

Anbar Journal of Agricultural Sciences
Volume 22, Issue 1, June 2024, Pages 82-94    PDF (565.88 K)
Document Type: Research Paper
DOI: 10.32649/ajas.2024.142234.1066
Authors
R. R. Abdul Kareem; Sh. H. Sayer
College of Education for Women- University of Anbar
Abstract
This study examined the possibility of using an alcoholic extract of S. costus root as a protective agent against chlorpromazine, which causes male infertility. The study divided white male rats into five groups, each containing six rats, for 30 days. The results revealed that the rats that received doses of chlorpromazine had significant changes in the hormones LH, FSH, and testosterone, in addition to a decrease in sperm motility, distortion of some sperm, and death of others. When injecting the rats with different doses of the alcoholic extract of the S. costus plant (at concentrations of 1.25 mg/kg, 2.4 mg/kg, and 4 mg/kg), in conjunction with doses of chlorpromazine at 2 mg/kg, there was no decrease in the aforementioned attributes. The histological test of the testicles showed significant changes in the histological structure of the testis in the group that received chlorpromazine. Both the amount of Leydig and Sertoli cells were reduced, as well as the average diameter of the seminiferous tubules, as a result of taking the drug. This led to a lower number of sperm-forming cells, the presence of gaps or spaces between the seminiferous tubules, and few or no mature sperm. Compared to the control group, the interstitial tissue was similarly dense, the spacing between the seminiferous tubules was reduced, and spermatogenic cells with mature spermatogonia appeared within the lumen of the tubules. There was a slight increase in the diameter of the seminiferous tubules and the number of Sertoli and Leydig cells compared to the control group. Seminiferous tubules and the average Leydig and Sertoli cell diameters increased significantly in the two groups at doses of 2.4 mg/kg and 4 mg/kg.
Keywords
Saussurea Costus; Rats; Chlorpromazine; Roots; Testes
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