the effect of biomarkers (leptin, hsCRP, ceruloplasmin) and their relationship to cardiovascular disease

Ridha, Zainab; Barry, Jamal Ahmed; Abd Al Bari, Abdalameer

doi:10.33762/mjbu.2024.144398.1165

	the effect of biomarkers (leptin, hsCRP, ceruloplasmin) and their relationship to cardiovascular disease
The Medical Journal of Basrah University
Article 8, Volume 42, Issue 1, June 2024, Pages 63-69 PDF (363.52 K)
Document Type: Research Paper
DOI: 10.33762/mjbu.2024.144398.1165
Authors
zainab ridha^* ¹; Jamal Ahmed barry²; Abdalameer Abd Al Bari³
¹college of medicine/ university of Basra
²Department of Biochemistry, Faculty of Medicine, University of Basrah
³University of Basrah/College of Medicine
Abstract
Background: Cardiovascular events can be seen in patients without classical cardiovascular risk factors, spurring the search for novel risk markers. Biomarkers are quantifiable bodily substances that indicate disease. Biomarkers have been studied concerning cardiovascular disease (CVD) to better understand their role in CVD development and progression. Biomarkers include Leptin, hs-CRP, and ceruloplasmin. These biomarkers cannot diagnose cardiovascular disease alone, but they can supplement risk factors and risk stratification. Method: This is a case-control study that included 90 coronary artery disease patients proved by coronary angiography. Included 53 males and 37 females, ages ranging from 25–45 years, who attended Al-Sadr Teaching Hospital and Basra Oil Specialized Cardiac Center, from December 2022 to March 2023. The patient's group were divided into a high-risk group and a low-risk group according to the clinical presentation & numbers of coronary vessel disease. On the other hand, 90 healthy participants matched in their age and sex to the patient’s group were included in the study. Leptin was measured by an enzyme-linked immunosorbent assay (ELISA) whereas ceruloplasmin and hs-CRP were assayed by electrochemiluminescence immunoassay (ECLIA) using Cobas e411. Results: Leptin and hs-CRP levels were significantly higher (p<0.05) while ceruloplasmin was significantly lower (P<0.05) in patients with coronary artery disease compared to age-matched healthy control subjects. These novel risk markers showed no significant statistical differences between high & low-risk groups of patients with coronary artery disease Conclusion: There is a positive relationship between the levels of leptin, hs-CRP & risk of CVD, which might be considered as a novel risk marker for the presence rather than severity of coronary artery disease
Keywords
Keywords: hs-CRP; cardiovascular disease; novel biomarkers

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