Evaluation of protein carbonyl levels as an indicator of protein oxidation in psoriasis patients

Adday, Wafaa Taresh; Alshakour, Abdulkader Abdulwahab; Dhahr, Samer Abdulameer

doi:10.33762/mjbu.2024.145169.1178

	Evaluation of protein carbonyl levels as an indicator of protein oxidation in psoriasis patients
The Medical Journal of Basrah University
Article 14, Volume 42, Issue 1, June 2024, Pages 107-114 PDF (338.18 K)
Document Type: Research Paper
DOI: 10.33762/mjbu.2024.145169.1178
Authors
wafaa taresh adday^* ¹; abdulkader abdulwahab alshakour²; samer abdulameer dhahr³
¹university of basrah, collage medicine, biochemistry department
²department biochemistry, collage of medicine, university of basrah
³Department of Medicine. College of Medicine,University of Basrah
Abstract
Background: Psoriasis is a persistent, non-infectious skin condition that impacts people of all ages and has no sex preference, which is caused by environmental stressors involving skin cells, immunocytes, and several biological signalling molecules. Recent studies propose that the underlying mechanisms of psoriasis may involve an elevated production of (ROS) and indicate that individuals with psoriasis exhibit elevated levels of reactive oxygen species (ROS) in their skin. Protein carbonylation is a widely adopted biomarker for indicating protein oxidation. The objective of this study was to examine serum protein carbonylation levels as a marker of protein oxidation in psoriasis patients, evaluating the impact of age, body mass index (BMI), and waist circumference (WC) on these levels. Methods: Conducted as a case-control investigation, this study enlisted 98 psoriasis patients and 81 healthy individuals, matched in terms of age and sex as controls. Blood samples, obtained through venipuncture (5 ml), were analyzed for protein carbonyl, random blood sugar, lipid profile, liver enzymes, and complete blood count (CBC). Results: The study found a significant difference in the mean value of serum protein carbonyl among patients with psoriasis as compared to the control group (3.82 ± 2.24 ng/ml vs. 3.28 ± 2.54 ng/ml) respectively (P<0.05). Conclusion: The study observed a non-significant negative correlation between levels of protein carbonyl and both age and the duration of psoriasis. Additionally, there was no significant negative correlation found between protein carbonyl levels and waist circumference, indicating that central obesity may render individuals more susceptible to protein oxidation, even when their BMI is found within the normal range.
Keywords
Keywords: Psoriasis; Protein carbonyl; and Protein oxidation

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