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A Study the antioxidant and anti-inflammatory activities of 5- selenocyanatouracil compound, against paracetamol induced oxidative stress | ||
| The Medical Journal of Basrah University | ||
| Article 4, Volume 42, Issue 1, June 2024, Pages 20-28 PDF (556.13 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.33762/mjbu.2024.145390.1180 | ||
| Authors | ||
| Nadheerah Falih Neamah* 1; Sahar Muayad Noori2; Shaker AS Al-Jadaan3 | ||
| 1university of Basrah-College of pharmacy | ||
| 2Alzubair General Hospital , Pharmacy Division, Basrah, Iraq | ||
| 3Pharmaceutical Chemistry- Department, College of Pharmacy/ University of Basrah, Iraq. | ||
| Abstract | ||
| Background: glutathione peroxidase, catalase, and superoxide dismutase enzymes are the main antioxidants that serve as the body's first line of defence against oxidative stress. The aim of the study: To examine 5-selenocyanatouracil anti-inflammatory and antioxidant properties. Materials and methods: Four groups of rats were employed; the control group received distilled water the paracetamol group received 500 mg/kg body weight of paracetamol, the paracetamol & 5-Selenocyanatouracil groups received 50 mg/kg of 5- selenocyanatouracil after 30 minutes of paracetamol, and the second paracetamol & 5-Selenocyanatouracil group received 100 mg/kg of 5-selenocyanatouracil after 30 minutes of paracetamol administration. Results: The findings demonstrated that 5-selenocyanatouracil considerably (p<0.05) raised levels of superoxide dismutase and glutathione reductase while notably lowering levels of Malondialdehyde and Interleukin-6. Conclusion: The findings showed that the prepared 5-selenocyanatouracil compound had antioxidant and anti-inflammatory activity. | ||
| Keywords | ||
| Keywords: 5-Selenocyanatouracil; Paracetamol; Glutathione reductase; Superoxide dismutase; Interleukin-6; Malondialdehyde | ||
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